Skin & Temperature control Flashcards

1
Q
  • what is core body temp
  • what does it vary with?
  • what happens above 41°C
  • what happens below 30°C
A
  • CBT is normally 37 +/- 0.5°C
  • varies with
  • external temperature
  • activity
  • menstrual cycle
  • circadian rhythm
  • above 41°C, proteins denature
  • below 30°C, lose consciousness
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2
Q

how is core body temp maintained?

A

by balacing heat loss and heat gain

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3
Q

What are the 4 factors that affect thermal balance and explain them

A
  • evaporation
  • respiration + sweating
  • radiation
  • radiation of heat, both into body ie through sun and out ie after exercise
  • accounts for 60% of heat loss
  • conduction
  • heat transfer direct between touching objects
  • convection
  • heat transfer due to bulk movement of molecules within gases and liquids
  • blood causes convection as it transfers heat from core to periphery ie skin
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4
Q

how do we detect body temperature?

A
  • cold and warm receptors
  • some receptors that fire when cold and others when warm
  • Range in middle when cold and warm fire at same rate
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5
Q

How can you tell warm and cold receptors apart?

A

via their dynamic response to change in temp: diagram

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6
Q

What are the different classes of thermoreceptors & where are they located?

A
  • peripheral thermoreceptors

located in skin, especially in face, scrotum as sperm needs to be kept cool

  • central thermoreceptors

located in spinal cord, abdominal organs, hypothalamus

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7
Q

In response to cold stress, how is heat generation within the body increased?

A
  • increased metabolism & background metabolic rate
  • Voluntary muscular activity
  • Shivering thermogenesis
  • involuntary muscle activity: use skeletal muscle, make it contract to produce heat as by-product
  • Non-shivering thermogenesis
  • only significant in infants, due to brown adipose tissue
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8
Q

in response to cold stress, how is heat loss from the body reduced?

A
  • sympathetic arterial constriction
  • behavioural responses ie adding clothing, moving to warmer environment
  • hypothermia- body temp reduced to 35°C
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9
Q

who are those at risk with the cold?

A
  • neonates
  • elderly
  • homeless
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10
Q

why are neonates at risk in the cold?

A
  • not much fat
  • don’t shiver well
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11
Q

why are the elderly at risk in the cold?

A
  • don’t detect temp change so well
  • less shivering capacity
  • more immobile
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12
Q

what is the treatment of cold stress?

A
  • dry/insulate to prevent further heat loss
  • slow re-warming with bag/blankets
  • internal re-warming with hot drinks and/or warm air
  • fast re-warming by immersion in water, extracorporeal circulation
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13
Q

what is a condition which arises as a response to cold stress?

A

frost bite

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14
Q

in frost bite, why may tissue damage occur?

A

may result from

  • direct cellular damage

or

  • secondary effects of vascular damage
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15
Q

how does vascular damage contirbute to frostbite?

A
  1. vasoconstriction
  2. increase in blood viscosity
  3. increase chance of clot
  4. thrombosis –> anoxia
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16
Q

how does cellular damage contribute to frostbite?

A
  1. ice crystals form in ECF
  2. increases extracellular osmolality
  3. draws fluid out of cells, they get dehydrated
  4. cell death
17
Q

what does cold stress cause?

A

increase in mortality

18
Q

in response to heat stress, heat production is minimised by what?

A
  • reduced food intake
  • decreased physical activity
19
Q

in response to heat stress, heat loss from the body is increased by?

A
  • arteriolar dilation
  • sweating - sympathetic cholinergic fibres increase evaporative heat loss
  • behavioural responses

-removing clothing, moving to shaded area

20
Q

what are some consequences of heat stress?

A
  • heat exhaustion
  • heat stroke
21
Q

what is heat exhaustion?

A
  • body temp raised in range 37.5- 40 degrees celsius
  • results in vasodilation and drop in central blood volume
  • caused by a disturbance of the body’s fluid/salt balance due to excessive sweating
22
Q

what are symptoms of heat exhaustion?

A
  • headache
  • confusion
  • nausea
  • clammy skin/profuse sweating
  • tachycardia
  • hypotension
  • fainting & collapse
23
Q

what is heat stroke?

A
  • body temperature raised to above 40degrees Celsius
  • body’s temp control mechanisms fail
24
Q

what are symptoms of heat stroke?

A

hot dry skin & circulatory collapse

25
who are the most at risk in heat?
* neonates & elderly * people doing physical work in hot humid environment * workers wearing non-breathable protective clothing
26
treatment of heat stress?
- move to cool environment - remove clothing - fan - sponge with tepid water - give fluids
27
* what is fever? * what is it caused by?
* part of body's mechanism for fighting infection * caused by endogenous pyrogens ie IL-1, IL-6
28
how does fever occur?
- endogenous pyrogens shift set point - caused by local production of prostaglandins by cyclo-oxygenase in hypothalamus
29
how do anti-pyretics such as aspirin and paracetamol reduce fever ?
by inhibiting enzyme cyclo-oxygenase & reducing levels of prostaglandins
30
what is fever's effect?
to increase set point so to regulate it around 39, so start doing things to increase core temperature to reach that ie shivering