Conditions from severe drug reactions Flashcards

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1
Q

What are 3 conditions that can arise due to a severe drug reaction?

A
  • Stevens Johnson Syndrome (SJS)
  • DRESS
  • Toxic Epidermal Necrolysis (TEN)
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2
Q

What are Stevens Johnson Syndrome/ Toxic Epidermal Necrolysis?

A

rare, severe reactions secondary to drugs

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3
Q

What is the clinical assessment of SJS?

A
  • fever
  • malaise
  • athralgia
  • rash
  • mouth ulceration
  • ulceration of other mucous membranes
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4
Q

although TEN & SJS are variants of the same condition, what is the main difference between SJS & TEN?

A
  • TEN has more epidermal detachment (30% vs 10% of SJS)
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5
Q

what percenatge of epidermal detachment is deemed a SJS/TEN overlap?

A

15-30%

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6
Q

what is the treatment for SJS?

A

supportive care

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7
Q

what is the clinical assessment of TEN?

A
  • often presents with prodromal febrile illness
  • ulceration of mucous membranes
  • rash ( may be macular, purpuric or blistering)
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8
Q

what is treatment for TEN?

A
  • identify & stop culprit drug asap
  • supprtive therapy
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9
Q

What is DRESS?

A

Dermal Reaction with Easinophilia & Systemic Symptoms

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10
Q

what is the typical onset for DRESS?

A

2-8weeks after drug exposure

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11
Q

what is the clinical assessment of DRESS?

A
  • fever
  • widespread rash
  • easinophilia
  • lymphadenopathy
  • deranged liver function
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12
Q

what is treatment for DRESS?

A
  • stop causative drugs
  • systemic drugs +/- immuno-suppression
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13
Q

what is erythroderma?

A
  • Any inflammatory skin disease affecting >90% of skin surface
  • can be caused by severe drug reactions
  • not a diagnosis, but rather a description
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