Skin Structure and Function 5 - Tutorial Flashcards
Spongiosis?
Intracellular edema
Parakeratosis?
Mode of keratinisation (keratin hardening) characterised by the retention of nuclei in the stratum corneum
Abscess?
A swollen area within body tissue containing an accumulation of pus
Rete pegs?
Downwards thickening of the epidermis between dermal papillae
6 requirements for healthy skin?
Intact physical barrier Functioning immune system Functioning vasculature/ adequate supply and drainage (arterial, venous, lymphatics and capillaries) Normal sensory nerve function Functioning sweat glands Adequate nutrition
What is slough?
What is it made of?
Necrotic tissue separating from living structure
Mixture of dead cells, polymorphs + bacteria
Should slough be removed from a wound?
Yes - has a negative effect on wound healing
How is slough removed from a wound?
Chemically or physically by debridement
What are the 3 stages of wound healing?
Inflammation
Proliferation
Tissue remodelling
What happens during inflammation in wound healing?
Platelets form initial clot and release inflammatory mediators
Leukocytes debride the wound bed by phagocytosing bacteria and scavenging cellular debris
Inflammation gradually decreases as keratinocyte proliferation and new tissue formation becomes predominant
What happens during proliferation in wound healing?
Cells divide to re-epitheliase the wound surface
Granulation tissue formation is stimulated
Fibroblasts lay down matrix and contract the wound (fibroplasia)
Epithelial cells develop into new blood vessels (angiogenesis)
What happens during tissue remodelling in wound healing?
New tissue is converted into mature scar tissue over a period of months
Fibroblasts lay down collagen to improve the tensile strength of the scar and restore the normal dermal matrix
Primary intention of surgical wounds?
An acute wound is closed by approximating wound edges
Secondary intention of surgical wounds?
Acute wound is left to heal on its own - takes longer but can produce satisfactory results
What is a burn?
Thermal injury to the skin