Skin Structure and Function 3 Flashcards
what is the dermo-epidermal junction?
interface between epidermis and dermis which holds them together
what is the role of the dermo-epidermal junction?
support/adhesion of basal cells
semi-permeable membrane so allows blood to diffuse across layers
what are the 3 layers of the dermo-epidermal junction?
lamina lucida
lamina densa
sub-lamina densa zone
give an example of what can happen if the dermo-epidermal junction fails?
bullous pemphigoid epidermolysis bullosa (problem with protein)
what problems can arise with the dermo-epidermal junction?
can have antibodies against the junction which can be shown by immunofluorescence
what is ground substance in the dermis?
collections of proteins that give structure to the dermis
what is contained within the dermis?
ground substance
cells - fibroblasts, macrophages, mast cells, lymphocytes, langerhans
fibres - collagen and elastin
muscles, vessels, lymphatics, nerves
what changes happen in the dermis to cause aging?
disordered collagen
disordered, broken up elastin
describe blood flow in the skin
horizontal plexuses
arteriole > precapillary sphincters > arteriole > venous capillaries > post-capillary venules > collecting venules
what are the 2 plexuses in the skin and what do they supply?
deep vascular plexus supplies the hair follicle
superficial vascular plexus just below epidermis
what is angioma?
benign overgrowth of blood vessels
disordered, not well formed blood vessels
describe lymphatic vessels in the skin?
sub-epidermal mesh networks/plexuses which continuously drain plasma proteins, cells and excess interstitial fluid
smaller non-contractile vessels > larger contractile lymphatic trunks
what are the immune functions of lymphatic vessels in the skin?
immune surveillance by circulating lymphocytes and Langerhans cells
channelling of micro-organisms and toxins
what is chronic lymphoedema?
increased pressure on lymphatic system (obesity/infection etc) means muscles cant pump the fluid back up and it gathers in lower limb
what nervous system controls sebaceous glands and arrector pili muscle?
autonomic