Skin Structure and Function 3 Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

what is the dermo-epidermal junction?

A

interface between epidermis and dermis which holds them together

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what is the role of the dermo-epidermal junction?

A

support/adhesion of basal cells

semi-permeable membrane so allows blood to diffuse across layers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what are the 3 layers of the dermo-epidermal junction?

A

lamina lucida
lamina densa
sub-lamina densa zone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

give an example of what can happen if the dermo-epidermal junction fails?

A
bullous pemphigoid
epidermolysis bullosa (problem with protein)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what problems can arise with the dermo-epidermal junction?

A

can have antibodies against the junction which can be shown by immunofluorescence

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what is ground substance in the dermis?

A

collections of proteins that give structure to the dermis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what is contained within the dermis?

A

ground substance
cells - fibroblasts, macrophages, mast cells, lymphocytes, langerhans
fibres - collagen and elastin
muscles, vessels, lymphatics, nerves

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what changes happen in the dermis to cause aging?

A

disordered collagen

disordered, broken up elastin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

describe blood flow in the skin

A

horizontal plexuses

arteriole > precapillary sphincters > arteriole > venous capillaries > post-capillary venules > collecting venules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what are the 2 plexuses in the skin and what do they supply?

A

deep vascular plexus supplies the hair follicle

superficial vascular plexus just below epidermis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what is angioma?

A

benign overgrowth of blood vessels

disordered, not well formed blood vessels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

describe lymphatic vessels in the skin?

A

sub-epidermal mesh networks/plexuses which continuously drain plasma proteins, cells and excess interstitial fluid
smaller non-contractile vessels > larger contractile lymphatic trunks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what are the immune functions of lymphatic vessels in the skin?

A

immune surveillance by circulating lymphocytes and Langerhans cells
channelling of micro-organisms and toxins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what is chronic lymphoedema?

A

increased pressure on lymphatic system (obesity/infection etc) means muscles cant pump the fluid back up and it gathers in lower limb

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what nervous system controls sebaceous glands and arrector pili muscle?

A

autonomic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what senses deep pressure?

A

pancinian corpuscles

17
Q

what is neurofibromatosis?

A

overgrowth of nerve endings causing multiple tumours

18
Q

what is the function of sebaceous oil?

A

lubricates hair and stops bacteria entering the follicle

19
Q

what causes whiteheads and blackheads?

A

whitehead = oil covered with skin so doesn’t oxidise
blackhead = oil oxidises and turns black
both result in inflammation and infection of pore

20
Q

what are the 3 types of gland in the skin?

A

sebaceous
apocrine
eccrine

21
Q

what do sebaceous glands do?

A

hormone sensitive secretion of sebum opening into pilary canal
most in face and chest

22
Q

what is the function of sebum?

A

controls moisture loss

protects from infection (mainly fungal)

23
Q

what do apocrine sweat glands do?

A

androgen dependant glands that produce oily fluid in axillae and perineum

24
Q

where are eccrine sweat glands found?

A

whole skin surface but palms, soles and axillae in particular

25
Q

what innervates eccrine sweat glands and what is the implication of this?

A

sympathetic cholinergic innervation

therefore stress, heat and spicy foods can activate them

26
Q

what is the function of eccrine sweat glands?

A

cool by evaporation
moisten palms and soles to aid grip
ultrafiltration function as they secrete hypotonic fluid by reabsorbing NaCl and HCO3