Week 1 formative Flashcards

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1
Q

what disease causes blistering of the back of the hands and excess hair growth (eg on the face)?

A

PCT (porphyria cutaenea tarda)

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2
Q

what cells are responsible for vitamin D metabolism?

A

keratinocytes

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3
Q

what cells are responsible for energy storage?

A

subcutaneous fat

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4
Q

what cells are responsible for epidermal proliferation?

A

basal cells

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5
Q

what cell release inflammatory mediators in the skin?

A

mast cells

Langerhans are antigen presenting cells

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6
Q

what is a main component of a virulent strain of MRSA which causes necrotising fasciitis?

A

PVL

Panton Valentine Leukocidin

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7
Q

Apocrine glands vs Eccrine glands?

A
apocrine = scent glands
eccrine = moisten hands and feet for grip
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8
Q

what is found in the dermis?

A

fibroblasts
ground substance
lymphatics

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9
Q

which enzyme is deficient in acute intermittent porphyria

A
Porphobilinogin Deaminase (PBG Deaminase)
3rd enzyme in production of haem
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10
Q

where are Odland bodies found?

A

granular layer

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11
Q

where are metabolically active cuboidal cells found?

A

basal layer

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12
Q

where are polyhedral cells with lots of desmosomes found?

A

prickle cell layer

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13
Q

what is required to maintain good circulation in the lower limb?

A

venous valves
muscle pump
pulse pressure

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14
Q

how much do finger nails grow per day?

A

0.1mm

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15
Q

painful and slightly red skin on sun exposure but normal on clinical examination?

A

erythropoetic protoporphyria

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16
Q

anagen?
catagen?
telogen?

A
anagen = growing phase
catagen = involuting phase
telogen = resting phase
17
Q

what are the most common sweat glands on the face?

A

eccrine sweat glands

18
Q

which enzyme is deficient in erythropoietic protoporphyria?

A

Ferrochelatase

final enzyme in production of haem

19
Q

where are melanocytes found?

A

directly above the basal layer which sits on top of the dermo-epidermal junction