Rash Clinical Cases Flashcards
what else can psoriasis affect as well as the skin?
nails - pitting, oncholysis, dystrophy, subungal hyperkeratosis
joints
what causes psoriasis?
multifactorial
genetic predisposition and environmental trigger - stress, drugs, infection
what is the most common form of psoriasis?
chronic plaque psoriasis (psoriasis vulgaris)
what is the koebner phenomenon?
psoriasis develops in scar, wound or area of trauma
what is auspitz sign?
removal of surface scale reveals tiny bleeding points due to capillaries in extended dermal papillae
give 3 other types of psoriasis?
guttate (after throat infection)
palmoplantar pustular (hands and feet)
erythrodermic/ pustular (drug induced)
how are inflammatory markers affected by psoriasis?
raised
does psoriasis affect life expectancy?
yes, by about 4 years due to increased cardiovascular risk
what are some comorbidities with psoriasis?
arthritis metabolic syndrome crohns cancer depression uveitis
what are 5 topical therapies for psoriasis?
Vit D analogues - calcipotriol - calcitriol coal tar dithranol steroid ointment (used in conjunction with other treatments) emollients (essential)
what non-topical treatments are used for psoriasis?
UVB and PUVA
Immunosuppression (methotrexate)
immune modulation
first line for acne?
topicals: - benzoyl peroxide - Vit A derivatives (retinoids) - antibiotics Systemic: - antibiotics (doxy)
second line for acne?
oral isotretinoin (systemic retinoid)
what happens with isotretinoin treatment?
causes initial flare 2-3 weeks in then improves over 16 weeks
pathogenesis of acne?
increases sebum production, pore occlusion, dermal inflammation, bacterial colonisation of duct