skin pathology Flashcards
Hyperkeratosis is…
increased thickness of the keratin layer
Parakeratosis is…
persistence of nuclei in the keratin layer.
Acanthosis is…
increased thickness of the epithelium
Papillomatosis is…
AN irregular epithelial thickening
-with papilla formation
Epidermal hyperplasia, complement-mediated attack on the keratin layer and Munro micro abscesses are characteristic of …
psoriasis
What are the features of Lichen planus on histology?
- irregular sawtooth Acanthosis
- Hypergranulosis
- band of lymphocyte infiltrate in the upper dermis
- basal layer damage
List 3 important Immunobullous disorders.
- Pemphigus
- Bullous pemphigoid
- Dermatitis herpetimormis
In Pemphigus vulgaris, IgG auto-antibodies are made against ____, resulting in blister formation in the ____ epidermal layer
Desmoglein 3, a desmosomal adhesion protein
Blisters in upper epidermis
Bullous pemphigoid gives rise to blisters. What layers are separated?
Basement membrane is detached from the basal cell layer of the epidermis.
What antibodies are produced in Bullous pemphigoid?
IgG against hemidesmosomes (basement membrane-basal layer attachment)
What antibody is involved in Dermatitis herpetiformis?
IgA against gliadin
-these also react with connective tissue matrix proteins
Dermatitis herpetiformis has a strong association with ___ ___
coeliac disease
