Dermatitis/Eczema

Question 1

What are the histological features of Eczema?

Answer 1

1. Spongiosis (oedema between keratinocytes)

2. Inflammatory cell infiltrate

Question 2

What lesions are present in the acute phase of eczema?

Answer 2

Papulovesicular, erythematous lesions, oozing, scaling and crusty

Question 3

What is the immunopathology of contact allergic dermatitis?

Answer 3

1. Langerhans cells process antigen in the epidermis
2. Antigen is presented to Th cells in the dermis
3. Sensitised Th cells migrate to lymphatics and regional nodes

Question 4

What test is used to diagnose contact allergic dermatitis?

Answer 4

Patch testing

• leave on skin for 48 h
• check reaction after 96h

Question 5

Skin erosions reach into the dermis (T/F)

Answer 5

False.

Erosions penetrate the epidermis only.

Question 6

Monomorphic punched-out lesions are characteristic of what infection secondary to atopic eczema?

Answer 6

Eczema herpeticum

-herpes simplex virus

Question 7

List the Eczema treatment options:

Answer 7

1. Emollients
2. Topical steroids
3. Phototherapy
4. Systemic immunosuppressants

Question 8

What is the cause of Lichen simplex?

Answer 8

Scratching