skin immunology

Question 1

Hypersensitivity is…

Answer 1

overreaction to antigen

Question 2

What is the Birbeck granule?

Answer 2

‘tennis racket’ Granules present in the Langerhans cells

Question 3

Langerhans cells’ role is…

Answer 3

antigen presentation

Question 4

What T cell type is mostly found in the epidermis?

Answer 4

CD8+ T cells

Question 5

___ T cells are mostly found in the dermis.

Answer 5

CD4+ T cells

Question 6

Function of Th1 helper cells?

Answer 6

macrophage activation

Question 7

Function of Th2 helper cells?

Answer 7

Th2 induce Ig production by B cells

Question 8

What dendritic cells are found in the dermis?

Answer 8

Dermal dendritic cells

Plasmacytoid dendritic cells

Question 9

What do dermal DC do?

Answer 9

present antigens

Question 10

Plasmacytoid DC produce large amounts of ____. They are found in ____ skin

Answer 10

INF-alpha

in diseased skin

Question 11

Mast cells bind ___ on the ____ surface

Answer 11

IgE

helminth/worm

Question 12

Class I MHC is found on what cell types?

Answer 12

all cell types.

Question 13

Class II MHC is found on ____ cells

Answer 13

Antigen presenting cells

-present exogenous antigen to Th cells

Question 14

What do filaggrin tripeptides do in the stratum corneum?

Answer 14

they bind water molecules, ensuring hydration of skin