skin last min Flashcards
which layer contains melanocytes?
Stratum basale
which layer contains ketatin
Stratum spinosum
Stratum corneum
Cells in this row
function
Corneocytes - horny cells
dead keratinocytes,
give structure
chemical barrier
water resistant
stratum lucidum
clear layer in soles and palms of hands and feet
transparent cells
reduce friction between
stratum granulosum and corneum
Stratum Granulusoum
cells
flat cells, no nuclei, allow them to have lots of keratin, hard rigid layer
which layer makes keratin
stratum spinosum
which layer makes melanocytes
stratum basale
Dermis
3 structural properties
-fibrous
-made of CT
-made of crosslinking collagen and elastin fibers
2 layers of dermis
Papillary layer
Reticular Layer
Dermis Layers Composition
Papillary Layer
highly vascular, loose, CT.
Dermis Layers Composition
Reticular Layer
Thick, dense, CT
Majority of layer
contains nerves, vessels, follicles, glands
Ehlers-Danlos Syndrome
Defect in what?
Collagen
Ehlers-Danlos Syndrome
What is seen on physical exam?
Hypermobility of joints bc weak CT
Elastic skin
Ehlers-Danlos Syndrome
Secondary Problems
Scoliosis/kyphosis
Ruptured arteries and organs
Thin corneas
Marfan syndrome
Defect in what?
Connective Tissue
Marfan syndrome
Cause?
FIBRILIN1 mutation
Codes for fibrillin and the elastic fibers of CT
Marfan Syndrome Appearance
Long narrow face
Tall thin build
digits long
scoliosis 60%
Sternum defects
_____% of people with Marfans develop changes in heart and vessels.
90
Marfans
Aortic aneurysm
Walls of aorta, become weak, bulge out and could rupture.
Usually aortic root
Marfans
Aortic dissection
Aorta tear, blood enters middle level
possible rupture
Marfans
Heart valve problems
weak valve, regrug
Squamous Cell carcinoma
Which layer and color
red elevation on skin
Stratum spinosum
Metastasize if not removed
Basal cell carcinoma
shape
% cure
% white ppl
Basal cell layer
DOme shape forms ulcer
99% curable
30% white
Melanoma
Layer?
% of skin cancers
Chance of survival is poor if the lesion
basal
5%
> 4mm
