Skin Disorder Flashcards
What is SJS + what are the sx
Rare immune-mediated skin reaction, usually triggered by medications
Prodromal flu-like illness: Fever >39C, sore throat, rhinorrhea, cough, aches
Sudden onset tender/painful skin rash on face/limbs, 90% with involvement of mucous membranes (mouth, eyes, genital)
Tender red/purple macules, diffuse erythema, targetoid lesions, bullae and/or vesicles (may have positive Nikolsky)
Melanoma sx, dx, rx, types (in order of commonness)
ABCDE (Asymmetry, Border, Colour, Diameter >6mm, Evolving/elevation)
Subtype frequency: superficial spreading > nodular > lentigo maligna > acral lentiginous
Diagnosis and treatment: full-thickness excisional biopsy with 0.5-2cm safety margin (according to Breslow thickness)
Prognosis highly dependent on Breslow thickness, 5-year survival drops with depth > 1-2 mm
Sx, dx, rx of BCC
Basal Cell Carcinoma
Nodular BCC (most common) - raised pearly white nodule with telangiectasia >6mm
Superficial BCC - red scaling plaques with thready border
Diagnosis and treatment: full or partial-thickness biopsy (at edge of lesion to contain normal tissue)
SCC sx, dx + rx
Persistent ulceration, crusting, hyperkeratosis, erythema
Treatment: Surgical excision + biopsy (e.g., punch biopsy, Mohs micrographic)
SCC In Situ: Bowen’s disease
Pre-malignancy: Actinic keratosis (AK), Leukoplakia (oral)
Treat local AK with cryotherapy (eg. two freeze thaw cycles of 5s)
Treat widespread AK with fluorouracil 5% cream BID x 2-6 weeks
Sx of Cutaneous T-cell lymphoma (Mycosis Fungoides)
Lymphocyte infiltration in progressive stages (slow course over years)
Pruritus → oval or annular patches → thickened plaque → tumors
Types + sx of pemphigus
Refers to a group of life-threatening autoimmune blistering and erosive diseases affecting the skin and mucosa (
Complications include infection, fluid loss, electrolyte disturbances
Types: Vulgaris (most common; 70% of all pemphigus), Foliaceus, IgA, Paraneoplastic
Rx for pemphigus
Systemic steroids (1-2mg/kg prednisone daily or 0.5-1mg/kg in combination with rituximab)
Azathioprine or mycophenolate mofetil are often used to attempt to reduce steroids
Consider adjunctive high potency topical steroid (e.g., clobetasol propionate) for larger erosions
Cover erosions with antibiotic ointment or a bland emollient (eg, petroleum jelly) +/- non-adhesive wound dressings
What is the rash associated with celiac?
Dermatitis Herpetiformis (“Celiac of the skin”)
Pruritic papulovesicular rash on extensor
Can biopsy to confirm celiac
Recurrent aphthous stomatitis
What skin conditions are associated with DM?
Acanthosis nigricans (seen in most patients with childhood diabetes)
Diabetic dermopathy (30% of patients with diabetes)
Light brown/red oval/round scaly patches usually in pretibial area
What is Kaposi’s sarcoma?
Common in AIDS and following organ transplant
Purple/black papular lesions, most commonly affecting lower limbs, back, face, mouth, genitalia
Cause of folliculitis
Pseudomonas aeruginosa
Management of folliculitis
Reassurance - resolves spontaneously
If immunocompromised: Ciprofloxacin 500mg po bid x 7-14 days
Dishydrotic Eczema?
(Pompholyx)
Associated with Atopy and Palmoplantar Hyperhidrosis
Keratosis Pilaris?
Hyperkeratinization of pillar follicles
Sebaceous Hyperplasia rx
Reassurance (cosmetic concern, no malignant potential)
Tretinoins
Anti-androgens (for female patients)
Where do you find Angioma Serpiginosum?
Buttocks
Lower Extremities
Paronychia rx?
Infection around nail
Trimethoprim/Sulfamethoxazole
Doxycycline
Clindamycin
Erythema migrans rx + complications
First sign of Lyme disease
Doxycycline
Amoxicillin
Cefuroxime
Complications:
Fever
Arthritis
Myalgias
Headaches
Fatigue
Cranial Nerve Palsies (CN VII)
Peripheral Neuropathy
Pericarditis
Heart Blocks
Encephalopathy
Meningitis
Solar lentigo
Hyperpigmentation caused by the proliferation of melanocytes and keratinocytes from UV exposure
What is Erythema toxicum neonatorum?
Occurs in 50% term babies, occurs day 2-5
Eyelid Dermatitis rx
Corticosteroids
Calcineurin Inhibitors
Macrolide Immunosuppressant
Rosacea aggravating factors
Alcohol
Heat
Cold
Stress
Caffeine
Treatment:
Doxycycline
Erythromycin
What to avoid in rosacea
Topical steroids
Auspitz sign?
Pinpoint bleeding with scale removal - psoriasis
Koebner’s phenomenon?
New lesions at site of injury - psoriasis
Management of psoriasis
Corticosteroids
Vitamin D Analogues
Retinoids
Salicyclic Acid
Tar
UV Light Therapy
Calcineurin Inhibitors - Tacrolimus
Biologicals
Psoriasis nails
Stippled
BCC features
History of UV exposure
Non-healing lesion
Easy/recurrent bleeding
Ulceration
Telangiectasia
Pearly Appearance
Raised Border
Central Depression
Previous history of BCC/SCC
Discoid lupus erythematosus features + treatment
Round, coin shaped lesions
Scaly, lighter centre
Topical/intralesional corticosteroids
Antimalarials (ex: hydroxycholorquine)
Tacrolimus
Pityriasis Rosea features and treatment
Initial “Herald Patch” followed by diffuse papulosquamous eruption in “Christmas Tree” distribution. May last 6-8 weeks.
Conservative management (control pruritic symptoms as needed; topical zinc oxide, calamine, corticosteroids or antihistamines)
Acne management
Topical antibiotics
Topical retinoids
Topical benzoyl peroxide
Oral antibiotics
Oral isotretinoin
Anti-androgenics
Dermatomyositis signs
Gottron’s sign/papules
Heliotrope/iliac rash
Shawl Sign
How to make dx of tinea
Fungal scraping for KOH preparation
Skin biopsy
Wood’s Lamp
Bullous pemphigoid dx and treatment
Biopsy of bulla margin
Direct immunofluorescence
Systemic steroids