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Onco Board Review 2 > Skin/Cutaneous LSA > Flashcards

Skin/Cutaneous LSA Flashcards

1
Q

Which T-cell subtype is malignant in canine epitheliotropic T-cell LSA?

A

CD8

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2
Q

What is Sezary syndrome?

A

cutaneous T-cell LSA with peripherally circulating malignant T-cells

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3
Q

Papillomavirus causes destabilization of p53 by what viral protein?

A

E6

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4
Q

Papillomavirus protein E7 inhibits which molecule?

A

Rb

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5
Q

What is the typical appearance of a feline basal cell carcinoma?

A

small pigmented mass often located on head or neck

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6
Q

What is the causative agent of feline fibropapillomas and equine sarcoids?

A

Bovine papillomavirus

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7
Q

Definition of SCC in situ?

A

carcinoma that has not yet penetrated basement membrane

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8
Q

What is the difference between Bowen’s carcinoma and actinic keratosis?

A

Bowen’s - multiple SCC in situ that develop unrelated to UV exposure
Actinic keratosis - SCC in situ that develop due to UV exposure

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9
Q

CR rate of feline nasal SCC treated with intralesional carbo/sterile sesame oil?

A

73%

55% 1 year PFS

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10
Q

T/F: Canine nasal planum SCC is RT responsive.

A

False

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11
Q

Which is highly metastatic?

  1. malignant trichoepithelioma
  2. pilomatricoma
  3. basal cell carcinoma
  4. infundibular keratinizing acanthoma
  5. trichoblastoma
A

malignant trichoepithelioma - LN and lungs

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12
Q

What is typical behavior of apocrine gland carcinomas?

A

local invasion common, distant metastasis rate is low

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13
Q

Renal cystadenocarcinoma and nodular dermatofibrosis is caused by mutation in what gene?

A

Follicular gene

Birt-Hogg-Dube - BHD

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14
Q

What is the treatment of choice for RCND?

A

None exists

Most die within 3 years of detection

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15
Q

T/F: Basal cell carcinoma is low grade in dogs.

A

True

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16
Q

Sr90 for feline SCC in situ results in survival times of ____?

A

> 3000 days (8.2 years)

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17
Q

What paraneoplastic syndrome has been reported in cats with cutaneous SCC?

A

HyperCa

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18
Q

What is the tx of choice for ceruminous gland ACA?

A

TECA and lateral bulla osteotomy

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19
Q

What are 4 prognostic factors for ear canal tumors in cats?

A
  1. mitoses per hpf (<2 or >3)
  2. extension beyond ear canal
  3. presence of neurologic signs
  4. histology (ceruminous vs. SCC vs. unknown)
20
Q

What is the most common digital tumor in dogs?

21
Q

What % of dogs with digital SCC have metastasis at diagnosis? What % later develop mets?

A
  1. 8% at dx

23. 2% later

22
Q

What is the MST for cats with lung-digit syndrome?

23
Q

What % of dogs with digital melanoma have evidence of metastasis at time of dx?

A

28%

38.5% later develop mets

24
Q

What is the 1 year survival rate for canine digital SCC?

25
What is the 1 year survival rate for canine digital melanoma?
42-57%
26
Cutaneous LSA most common in what breeds?
Scotties, Boxers, Goldens (Villamil 2011)
27
Most common cutaneous neoplasms of horses? Predisposed breeds?
sarcoid, SCC, melanoma Thoroughbreds - cutaneous LSA Arabians - melanoma
28
Expression of ___ is essential for homing of cutaneous LSA to skin.
CCR4
29
Which breeds are predisposed to cutaneous LSA?
Boxers and cockers
30
What is the response rate to CCNU for cutaneous LSA?
78-83%
31
What was identified in 10/17 cutaneous LSA tumors at injection sites of cats? Most were what type of LSA? (Roccabianca 2016)
FeLV Most were large B cell Inflammation and reactivation of FeLV expression may contribute to emergence
32
What was the most common form of tarsal LSA in cats? What % had involvement of another site at death/euth? (Burr 2014)
nonepitheliotropic, high grade | 56% (22% had popliteal LN involvement at dx)
33
What was the ORR to VDC-1101 (Tanovea) for cutaneous LSA? (Morges 2014)
45% | biologic response rate of 64%
34
What two drugs have yielded the highest rate of complete remission for cutaneous LSA? (Laprais 2017)
CCNU and pegylated liposomal DOX
35
What was MST without treatment vs. with CCNU for cutaneous LSA? (Laprais 2017)
No tx - 3-5 months | CCNU - 6 months - conclude that it can lead to CR but of short duration
36
What was ORR of cutaneous LSA to masitinib? What % had CR and for how long? (Holtermann 2016)
70% | CR was 20%, lasted for 85d
37
What was KIT receptor expression of cutaneous LSA? (Holtermann 2016)
All were KIT negative, masitinib likely acting through a different target
38
What factors were associated with shorter survival for canine cutaneous LSA? (Chan Vet Derm 2018)
cutaneous form, presence of multiple lesions
39
What factors were associated with longer survival for canine cutaneous LSA? (Chan Vet Derm 2018)
chemotherapy treatment, solitary lesions
40
What treatments showed benefit for dogs with multiple cutaneous lesions? (Chan Vet Derm 2018)
retinoids and chemo
41
What % of dogs with solitary cutaneous lesions developed additional lesions or nodal metastasis? (Chan Vet Derm 2018)
50%
42
What % of dogs with solitary mucocutaneous and mucosal lesions eventually developed new lesions? At what time point? (Chan Vet Derm 2018)
28.8% median of 275d (9.2 months) (remaining 71.2% did not develop additional lesions for median follow up of 501d)
43
For dogs with localized oral mucocutaneous lymphoma, what was ORR to RT and MST? (Berlato 2011)
``` ORR 67% MST 770d (2.1 years) ```
44
What % of dogs with localized oral mucocutaneous LSA had involvement of mandibular LN on staging? (Berlato 2011)
50% (6/12) identified on either cyto or biopsy
45
What % of dogs with localized oral mucocutaneous LSA developed progressive disease (local or systemic)? (Berlato 2011)
50% (7/14) 2 - local (14%) 4 - systemic (29%)
46
What breed was over-represented in the Berlato study of localized oral mucocutaneous LSA?
Boxers (43%, outcome did not differ)

Onco Board Review 2 (20 decks)

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