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Onco Board Review 2 > Skin/Cutaneous LSA > Flashcards

Skin/Cutaneous LSA Flashcards

1
Q

Which T-cell subtype is malignant in canine epitheliotropic T-cell LSA?

A

CD8

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2
Q

What is Sezary syndrome?

A

cutaneous T-cell LSA with peripherally circulating malignant T-cells

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3
Q

Papillomavirus causes destabilization of p53 by what viral protein?

A

E6

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4
Q

Papillomavirus protein E7 inhibits which molecule?

A

Rb

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5
Q

What is the typical appearance of a feline basal cell carcinoma?

A

small pigmented mass often located on head or neck

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6
Q

What is the causative agent of feline fibropapillomas and equine sarcoids?

A

Bovine papillomavirus

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7
Q

Definition of SCC in situ?

A

carcinoma that has not yet penetrated basement membrane

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8
Q

What is the difference between Bowen’s carcinoma and actinic keratosis?

A

Bowen’s - multiple SCC in situ that develop unrelated to UV exposure
Actinic keratosis - SCC in situ that develop due to UV exposure

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9
Q

CR rate of feline nasal SCC treated with intralesional carbo/sterile sesame oil?

A

73%

55% 1 year PFS

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10
Q

T/F: Canine nasal planum SCC is RT responsive.

A

False

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11
Q

Which is highly metastatic?

  1. malignant trichoepithelioma
  2. pilomatricoma
  3. basal cell carcinoma
  4. infundibular keratinizing acanthoma
  5. trichoblastoma
A

malignant trichoepithelioma - LN and lungs

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12
Q

What is typical behavior of apocrine gland carcinomas?

A

local invasion common, distant metastasis rate is low

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13
Q

Renal cystadenocarcinoma and nodular dermatofibrosis is caused by mutation in what gene?

A

Follicular gene

Birt-Hogg-Dube - BHD

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14
Q

What is the treatment of choice for RCND?

A

None exists

Most die within 3 years of detection

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15
Q

T/F: Basal cell carcinoma is low grade in dogs.

A

True

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16
Q

Sr90 for feline SCC in situ results in survival times of ____?

A

> 3000 days (8.2 years)

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17
Q

What paraneoplastic syndrome has been reported in cats with cutaneous SCC?

A

HyperCa

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18
Q

What is the tx of choice for ceruminous gland ACA?

A

TECA and lateral bulla osteotomy

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19
Q

What are 4 prognostic factors for ear canal tumors in cats?

A
  1. mitoses per hpf (<2 or >3)
  2. extension beyond ear canal
  3. presence of neurologic signs
  4. histology (ceruminous vs. SCC vs. unknown)
20
Q

What is the most common digital tumor in dogs?

A

SCC

21
Q

What % of dogs with digital SCC have metastasis at diagnosis? What % later develop mets?

A
  1. 8% at dx

23. 2% later

22
Q

What is the MST for cats with lung-digit syndrome?

A

4.9 weeks

23
Q

What % of dogs with digital melanoma have evidence of metastasis at time of dx?

A

28%

38.5% later develop mets

24
Q

What is the 1 year survival rate for canine digital SCC?

A

50-83%

25
Q

What is the 1 year survival rate for canine digital melanoma?

A

42-57%

26
Q

Cutaneous LSA most common in what breeds?

A

Scotties, Boxers, Goldens (Villamil 2011)

27
Q

Most common cutaneous neoplasms of horses? Predisposed breeds?

A

sarcoid, SCC, melanoma
Thoroughbreds - cutaneous LSA
Arabians - melanoma

28
Q

Expression of ___ is essential for homing of cutaneous LSA to skin.

A

CCR4

29
Q

Which breeds are predisposed to cutaneous LSA?

A

Boxers and cockers

30
Q

What is the response rate to CCNU for cutaneous LSA?

A

78-83%

31
Q

What was identified in 10/17 cutaneous LSA tumors at injection sites of cats? Most were what type of LSA? (Roccabianca 2016)

A

FeLV
Most were large B cell
Inflammation and reactivation of FeLV expression may contribute to emergence

32
Q

What was the most common form of tarsal LSA in cats? What % had involvement of another site at death/euth? (Burr 2014)

A

nonepitheliotropic, high grade

56% (22% had popliteal LN involvement at dx)

33
Q

What was the ORR to VDC-1101 (Tanovea) for cutaneous LSA? (Morges 2014)

A

45%

biologic response rate of 64%

34
Q

What two drugs have yielded the highest rate of complete remission for cutaneous LSA? (Laprais 2017)

A

CCNU and pegylated liposomal DOX

35
Q

What was MST without treatment vs. with CCNU for cutaneous LSA? (Laprais 2017)

A

No tx - 3-5 months

CCNU - 6 months - conclude that it can lead to CR but of short duration

36
Q

What was ORR of cutaneous LSA to masitinib? What % had CR and for how long? (Holtermann 2016)

A

70%

CR was 20%, lasted for 85d

37
Q

What was KIT receptor expression of cutaneous LSA? (Holtermann 2016)

A

All were KIT negative, masitinib likely acting through a different target

38
Q

What factors were associated with shorter survival for canine cutaneous LSA? (Chan Vet Derm 2018)

A

cutaneous form, presence of multiple lesions

39
Q

What factors were associated with longer survival for canine cutaneous LSA? (Chan Vet Derm 2018)

A

chemotherapy treatment, solitary lesions

40
Q

What treatments showed benefit for dogs with multiple cutaneous lesions? (Chan Vet Derm 2018)

A

retinoids and chemo

41
Q

What % of dogs with solitary cutaneous lesions developed additional lesions or nodal metastasis? (Chan Vet Derm 2018)

A

50%

42
Q

What % of dogs with solitary mucocutaneous and mucosal lesions eventually developed new lesions? At what time point? (Chan Vet Derm 2018)

A

28.8%
median of 275d (9.2 months)
(remaining 71.2% did not develop additional lesions for median follow up of 501d)

43
Q

For dogs with localized oral mucocutaneous lymphoma, what was ORR to RT and MST? (Berlato 2011)

A 
ORR 67%
MST 770d (2.1 years)
44
Q

What % of dogs with localized oral mucocutaneous LSA had involvement of mandibular LN on staging? (Berlato 2011)

A

50% (6/12) identified on either cyto or biopsy

45
Q

What % of dogs with localized oral mucocutaneous LSA developed progressive disease (local or systemic)? (Berlato 2011)

A

50% (7/14)
2 - local (14%)
4 - systemic (29%)

46
Q

What breed was over-represented in the Berlato study of localized oral mucocutaneous LSA?

A

Boxers (43%, outcome did not differ)

Onco Board Review 2 (20 decks)

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