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Onco Board Review 2 > Cardiac/Respiratory > Flashcards

Cardiac/Respiratory Flashcards

1
Q

Which type of asbestos is associated with greater risk for developing mesothelioma in humans?

A

amphibole

fibers are thin and rod-like

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2
Q

To what depth does local penetration of intracavitary chemotherapy occur?

A

2-3mm

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3
Q

What is the most common primary/metastatic cardiac tumor in cats?

A

Lymphoma

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4
Q

What serum biomarker is useful for diagnosing cardiac HSA in dogs?

A

cardiac troponin I

cTnI >2.45 indicated cardiac involvement likely in dogs with HSA

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5
Q

What is the MST for dogs with R atrial HSA treated with surgery alone? What about tumor resection + chemo?

A

46 days - 5 months

Sx + chemo = 164d (5.5 months)

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6
Q

What is the response rate of presumed cardiac HSA to DOX? (Mullin 2014)

A

CR + PR: 41%
SD: 68%
PFS 66d, MST 116d

(other reports - 50% shrink, 25% SD)

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7
Q

What is the MST for dogs with an aortic body tumor that undergo pericardiectomy?

A

730d (24 months)

No pericardiectomy 42d

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8
Q

What % of cats are disease free at 1 year after nosectomy for nasal planum SCC?

A

> 80%

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9
Q

What are the most common primary lung tumors in dogs? Cats?

A

Dogs: 85% bronchoalveolar
Cats: 60-70% adenocarcinoma

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10
Q

What is the metastatic rate of canine primary lung SCC?

A

50%

anaplastic carcinoma = 90%

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11
Q

What % of cats with primary lung tumors develop metastasis?

A

76%

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12
Q

T/F: Thyroid transcription factor 1 can differentiate a primary lung tumor from a metastatic carcinoma.

A

True

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13
Q

What is the reported complication rate for CT-guided biopsy of primary lung tumors?

A

43%

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14
Q

What is the RR of canine primary lung tumors to vinorelbine?

A

28.5%

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15
Q

Name 5 prognostic factors for primary lung tumors in dogs.

A
  1. size >100 cm3 (5cm diameter)
  2. LN involvement, other metastasis
  3. C/S at diagnosis
  4. Histologic type and grade
  5. peripheral vs. central
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16
Q

What is the most consistently reported prognostic factor for primary lung tumors in cats?

A

histologic grade

23 months well-differentiated, 2.5 months poorly differentiated

17
Q

Name 2 predictive factors for response to radiation therapy in feline nasal lymphomas.

A 
High Ki67 (>40%) -- more cats respond and live longer
High apoptotic index -- more cats respond, but don't have longer MST
18
Q

What complications occurred after SBRT (30 Gy) for heart-base tumors? (Magestro 2018)

A

arrhythmias, sudden death
(tumor volume decreased by 30-76% in those re-evaluated but authors conclude that SBRT in this fashion may not be ideal for asymptomatic, slowly growing tumors)

19
Q

What was the survival time with DOX-based treatment for R atrial masses with pericardial effusion? (Ghaffari JSAP 2014)

A

139.5 days

don’t think they had histopath, dogs excluded if protocol didn’t include DOX or if they had any form of surgery

20
Q

T/F: RT may improve incidence of cardiac tamponade for R atrial masses.

A

T (Nolan 2017)

21
Q

T/F: Cardiac troponin I is significantly increased after DOX and is correlated with development of cardiomyopathy.

A

False - cTnI did increase after DOX but was not correlated with cardiomyopathy.

22
Q

T/F: CXR are highly Sp but not Sn for detecting heart base masses.

A

True

23
Q

In a study evaluating primary and secondary heart tumors in dogs and cats, what % of dogs had cardiac metastases? (Aupperle 2007)

A

36%

24
Q

What was the MST for dogs with cardiac LSA and pericardial effusion treated with chemo? (MacGregor 2005)

A

157d (5.2 months)

25
Q

A plasma concentration of > ____ ng/mL can be used to detect cardiac HSA. (Chun 2010)

A

0.25

26
Q

What are two negative prognostic factors prior to surgery in cats with pulmonary neoplasia? (Nunley 2015)

A

LN enlargement, pleural effusion

MST w/LN - 65d vs. w/out 498d

27
Q

In another study from 2014, what were the 4 negative prognostic factors for cats with lung tumors? (Maritato 2014)

A
  1. presence of clinical signs
  2. pleural effusion
  3. moderately/poorly differentiated tumors (tumor grade)
  4. metastasis (any stage beyond T1N0M0)
28
Q

What breed was over-represented in one study of feline pulmonary carcinoma? (D’Costa 2012)

A

Persians

29
Q

What 3 radiographic lung tumor findings were most consistent with histiocytic sarcoma? (Barrett 2014)

A

Large mass in the periphery, affecting the whole lobe of right middle or left cranial lung lobes, internal air bronchogram

30
Q

What was the significance of EGFR expression in canine primary lung tumors? (Sabattini 2013)

A

increased expression may be associated with poor prognosis and was correlated with anthracosis (inflammation secondary to air pollution)

31
Q

What was the perioperative mortality for dogs and cats with thymic epithelial tumors? Survival? (Garneau 2015)

A

Mortality: 20% dogs, 22% cats
Survival: 1.7 yrs dogs, 3.7 yrs cats

32
Q

What % of dogs with thymomas had hypercalcemia? myasthenia graves? What % had tumor recurrence? (Robat 2013)

A

hyperCa 34%
myasthenia 17%
tumor recurrence 17%

33
Q

What % of dogs with thymoma have concurrent MG?

A

40%

34
Q

How can flow cytometry help differentiate thymoma from LSA?

A

In thymoma, all cases had 10% lymphocytes co-expressing CD4 and CD8

35
Q

What is the mean ST for dogs with R atrial HSA treated with surgery alone?

A

46d to 5 months

36
Q

What is the MST for dogs with an aortic body tumor that undergo pericardiectomy?

A

730d (24 months)

42d without pericardiectomy

Onco Board Review 2 (20 decks)

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