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Derm Pharm > Skin CA > Flashcards

Skin CA Flashcards

1
Q

HPV trx

A

imiquimod

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1
Q

BRAF inhibition

A

vemurafenib

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2
Q

retinal pigment epithelium detachment

A

trametinib

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3
Q

Genetic testing

A

vemurafenib trametinib

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4
Q

Caution in autoimm disease, cardiac disease, depression, infection

A

interferon

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4
Q

dermatitic, including toxic epidermal necrolysis

A

ipilimumab

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6
Q

iritis, retinal vein occlusion, uvetis

A

vemurafenib

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8
Q

Photosensitivity

A

imiquimod vemurafenib

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8
Q

Blood dyscrasia

A

sorafenib trametinib interferon

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8
Q

indiscriminant T cell activation

A

ipilimumab

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8
Q

blocks hedgehog via adenosine R

A

imiquimod

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9
Q

intrauterine fetal death

A

vismodegib

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9
Q

LV dysf

A

trametinib

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10
Q

decreased mental status, corticol blindness ataxia

A

aldesleukin

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10
Q

Diarrhea

A

trametinib

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11
Q

cutaneous SCC arises in 1/4 of patients

A

vemurafenib

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13
Q

Rash

A

vemurafenib trametinib imiquimod sorafenib ipilimumab

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15
Q

PULM

A

aldesleukin interferon trametinib

17
Q

Secondary tumors

A

vemurafenib

18
Q

Hepatic toxicity

A

aldesleukin interferon sorafenib vemurafenib

18
Q

Pneumonia and pulmonary infiltrates

A

interferon

18
Q

QT prolongation

A

vemurafenib

19
Q

BCC

A

imiquimod vismodegib

20
Q

CV

A

vemurafenib trametinib interferon aldesleukin

20
Pulm, GI, and brain bleeding
sorafenib
21
Binds IL2 =\> expands anti-tumor lymphocyte population
aldesleukin
23
Category D
sorafenib vemurafenib trametinib vismodegib
24
male-mediated teratogenicity
vismodegib
25
Endocrinopathies
ipilimumab
26
RAF kinase = target
sorafenib
27
SJS
vemurafenib
29
Category C
aldesleukin interferon imiquimod ipilimumab
31
Must have normal CV, pulm, renal function
aldesleukin
32
contraception needed + no blood donation x7mo
vismodegib
34
hypotension, SVT
aldesleukin
36
Not for organ transplant recipients
aldesleukin
37
TH1, TNF-alpha, IL
imiquimod
38
MEK = target
trametinib
39
BBW: Guillain-Barre, myasthenia gravis, pregnancy
ipilimumab
40
Renal capillary leak syndrome
aldesleukin
41
CTLA4 antigen
ipilimumab
42
Suicidal ideation
interferon
43
"eye"
vemurafenib trametinib

Derm Pharm (5 decks)

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