Acne, Psoriasis Flashcards
monitor for depression/suicidal symptoms
isotretinoin
p75 TNF receptor
etanercept
Increases reactivity to UVR due to MMP inhibition
topical retinoids
S/E of corticosteroids?
cushing syndrome; dermal atrophy; corticoid rosacea; increased intraocular pressure; acne;
contraindicated in sepsis
etanercept
Prodrug
benzoyl peroxide (benzoic acid > free radicals)
Mild corticosteroid?
hydrocortisone
hypercalcemia => causing abd pain, depression, fatique, weight loss
calcipotriene
ustekinumab MOA
suppresses formation of pro-inflammatory TH1 and TH17 (via binding of p40 => disruption of IL12/IL23)
musculoskeletal symptoms
RAR selective retinoids tretinoin, adapalene, tazarotene
salicylic acid MOA
keratolytic + causes desquamation of horny layer of skin
hormonally active form of vit D3
calcitriol
binds TNF-alpha
adalimumab, etanercept, infliximab
Moderate-strength corticosteroid?
betamethasone
treats adult RA only
infliximab
contraindicated in heart failure, murine protein sensitivity
infliximab
Very potent corticosteroid?
clobetasol propionate
MOA of tretinoin, adapalene, tazarotene
bind RAR, affecting cellular diff and prolif
increased risk of infection and neoplasm
ustekinumab
neonatal toxicity via breast milk or contact
salicylic acid
better tolerated on sensitive skin than calcipotriene
calcitriol
IV psoriasis medication
infliximab
vitamin D analog
calcipotriene
retinoid (related to vitamin A)
acitretin
