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Derm Pharm > Antifungals, Hair > Flashcards

Antifungals, Hair Flashcards

1
Q

hepatotoxicity

A

voriconazole, terbinafine (rare), posaconazole, itraconazole, fluconazole

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1
Q

Sexual dysfunction, loss of libido, feminization

A

finasteride

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2
Q

Distributes to breast milk

A

itraconazole

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3
Q

CYP

A

voriconazole, posaconazole, itraconazole, fluconazole

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4
Q

increased effects with saw palmetto

A

finasteride

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4
Q

decreases DHT concentrations in serum/scalp

A

finasteride

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4
Q

disfavored in young patients w/ immature BBB

A

ivermectin

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6
Q

QT prolongation and dysrhythmia

A

voriconazole, posaconazole, fluconazole

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6
Q

Permethrin MOA

A

binds voltage gated Na channels, causing hyperexcitability and paralysis (not effective against human Na channels)

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7
Q

Optic neuritis

A

voriconazole

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8
Q

methoxsalen MOA

A

activated by UVA, which leads to cross linking and conj of DNA (=cell death)

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8
Q

ovicidal

A

mathalon

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8
Q

lindane contraindications

A

uncontrolled seizure d/o

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9
Q

oral anti-lice trx

A

ivermectin

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9
Q

anti-louse which may increases liver enzymes

A

ivermectin

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10
Q

resistance driven by kdr mutation

A

permethrin

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11
Q

lindane BBW

A

skin d/o, neonatal prematurity

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13
Q

Itraconazole BBW

A

heart failure, ventricular dysf, co-administration with drugs

15
Q

Block ergosterol synthesis

A

amorolfine, fluconazole, itraconazole

16
Q

Asthma exacerbation in pts allergic to ragweed

A

permethrin

17
Q

MOA of malathion

A

metabolized to malaoxon in louse which inhibits AChEsterase

18
Q

Trypanostatic

A

eflornithine

20
Q

do not combine with topical azoles

21
Q

Should be taken with a meal or carbonated drink

A

posaconazole

22
Q

contraception for ~2mo after d/c

A

itraconazole

23
Q

lindane MOA

A

GABA blockade

24
Q

avoid if ICH

A

terbinafine

25
Q

Contraindicated post partum

A

itraconazole

26
Q

Locally bactericidal

28
Q

anti-inflammatory

29
Q

Category D

A

voriconazole, fluconazole

30
Q

Category B

A

terbinafine, naftifine

31
Q

ivermectin MOA

A

bunds glutamate-gated Cl channels (invertebrate nerve/muscle cells)

32
Q

may worsen bronchial asthma

A

ivermectin

34
Q

MOA of eflornithine

A

decreases ornithine decarboxylase, which decreases cell division and differentiation in hair follicles

35
Q

persists in environment

37
Q

Category C

A

posaconazole, itraconazole

38
Q

Must continue trx to maintain effects

39
Q

testosterone analog, blocks 5-alpha-reductase activity

A

finasteride

40
Q

S/E of mathalon if ingested?

41
Q

potential seizures/death

42
Q

MOA of ciclopirox

A

blocks fungal transmem transport = no essential substrates (interferes w DNA/RNA synth)

43
Q

Photosensitivity

A

voriconazole *SCC, M

Derm Pharm (5 decks)

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