Antifungals, Hair

Question 1

hepatotoxicity

Answer 1

voriconazole, terbinafine (rare), posaconazole, itraconazole, fluconazole

Question 1

Sexual dysfunction, loss of libido, feminization

Answer 1

finasteride

Question 2

Distributes to breast milk

Answer 2

itraconazole

Question 3

CYP

Answer 3

voriconazole, posaconazole, itraconazole, fluconazole

Question 4

increased effects with saw palmetto

Answer 4

finasteride

Question 4

decreases DHT concentrations in serum/scalp

Answer 4

finasteride

Question 4

disfavored in young patients w/ immature BBB

Answer 4

ivermectin

Question 6

QT prolongation and dysrhythmia

Answer 6

voriconazole, posaconazole, fluconazole

Question 6

Permethrin MOA

Answer 6

binds voltage gated Na channels, causing hyperexcitability and paralysis (not effective against human Na channels)

Question 7

Optic neuritis

Answer 7

voriconazole

Question 8

methoxsalen MOA

Answer 8

activated by UVA, which leads to cross linking and conj of DNA (=cell death)

Question 8

ovicidal

Answer 8

mathalon

Question 8

lindane contraindications

Answer 8

uncontrolled seizure d/o

Question 9

oral anti-lice trx

Answer 9

ivermectin

Question 9

anti-louse which may increases liver enzymes

Answer 9

ivermectin

Question 10

resistance driven by kdr mutation

Answer 10

permethrin

Question 11

lindane BBW

Answer 11

skin d/o, neonatal prematurity

Question 13

Itraconazole BBW

Answer 13

heart failure, ventricular dysf, co-administration with drugs

Question 15

Block ergosterol synthesis

Answer 15

amorolfine, fluconazole, itraconazole

Question 16

Asthma exacerbation in pts allergic to ragweed

Answer 16

permethrin

Question 17

MOA of malathion

Answer 17

metabolized to malaoxon in louse which inhibits AChEsterase

Question 18

Trypanostatic

Answer 18

eflornithine

Question 20

do not combine with topical azoles

Answer 20

naftifine

Question 21

Should be taken with a meal or carbonated drink

Answer 21

posaconazole

Question 22

contraception for ~2mo after d/c

Answer 22

itraconazole

Question 23

lindane MOA

Answer 23

GABA blockade

Question 24

avoid if ICH

Answer 24

terbinafine

Question 25

Contraindicated post partum

Answer 25

itraconazole

Question 26

Locally bactericidal

Answer 26

naftifine

Question 28

anti-inflammatory

Answer 28

naftifine

Question 29

Category D

Answer 29

voriconazole, fluconazole

Question 30

Category B

Answer 30

terbinafine, naftifine

Question 31

ivermectin MOA

Answer 31

bunds glutamate-gated Cl channels (invertebrate nerve/muscle cells)

Question 32

may worsen bronchial asthma

Answer 32

ivermectin

Question 34

MOA of eflornithine

Answer 34

decreases ornithine decarboxylase, which decreases cell division and differentiation in hair follicles

Question 35

persists in environment

Answer 35

lindane

Question 37

Category C

Answer 37

posaconazole, itraconazole

Question 38

Must continue trx to maintain effects

Answer 38

minoxidil

Question 39

testosterone analog, blocks 5-alpha-reductase activity

Answer 39

finasteride

Question 40

S/E of mathalon if ingested?

Answer 40

SLUDGEBBB

Question 41

potential seizures/death

Answer 41

lindane

Question 42

MOA of ciclopirox

Answer 42

blocks fungal transmem transport = no essential substrates (interferes w DNA/RNA synth)

Question 43

Photosensitivity

Answer 43

voriconazole \*SCC, M