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Derm Pharm > Hyperhidrosis, Leprosy > Flashcards

Hyperhidrosis, Leprosy Flashcards

1
Q

inhibits pathway involved in neutrophil chemotaxis

A

dapsone

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1
Q

increases toxicity of dapsone

A

rifampin

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2
Q

Where are eccrine sweat glands?

A

feet forehead palm cheek

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2
Q

discolors body fluids

A

rifampin clofazimine

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2
Q

immunosuppresive leprosy trx

A

clofazimine

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3
Q

hepatitis and jaundice (leprosy trx)

A

clofazimine

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4
Q

rifampin MOA

A

inhibits bacterial DNA-dep-RNA polymerase

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4
Q

clofazimine MOA?

A

binds mycobacterial guanine in DNA (mycobac have more GC than humans)

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5
Q

anti-angiogenic and teratogenic (leprosy trx)

A

thalidomide

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7
Q

Dapsone syndrome

A

hemolysis, methoglobinemia, hepatitis, cholestatic jaundice, periph neuropathy, hypoalbuminemia, psychosis, leukopenia, agranulocystosis

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8
Q

Botulinum s/e?

A

systemic botulism (rare) dry mouth HA fatigue neck pain eye problems

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10
Q

Botulinum toxin heavy chain binds:

A

cell membrane

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11
Q

Causes Steven Johnson syndrome

A

dapsone

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12
Q

rash on upper limbs and forehead (leprosy trx)

A

dapsone

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13
Q

severe liver toxicity; CYP inducer (leprosy trx)

A

rifampin

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14
Q

Glycopyrrolate MOA

A

anticholinergic antimuscarinic

15
Q

folate antagonist

16
Q

competes for active site of dihydropteroate synthetase

17
Q

Botulinum blocks:

A

nicotinic R muscarinic R

18
Q

Where are apocrine sweat glands?

A

axilla urogenital

19
Q

hematuria, hemaglobinuria (leprosy trx)

21
Q

Increases serum dapsone

A

trimethoprin

22
Q

minocycline MOA

A

inhibits ribosome 30S subunit

23
Q

dose-dependent anti-inflammatory action (leprosy trx)

A

clofazimine

24
Q

somnolence

A

thalidomide

25
Q

thalidomide MOA

A

blocks TNF-alpha production, thus blocking leukocyte migration (via Nfkb mediated transcriptional regulation)

26
Q

decreases toxicity of dapsone

A

cimetidine and omeprazole

27
Q

Drug that contains albumin

A

Botulinum toxin

29
Q

Botulinum toxin light chain:

A

cleaves SNAP25, which enables fusion of ACh vesicles with cell membrane

30
Q

Increases HIV viral load

A

thalidomide

Derm Pharm (5 decks)

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