Abx, Antivirals

Question 1

Linezolid MOA

Answer 1

blocks protein synthesis by binding 23S RNA on ribosome subunit

Question 1

lactic acidosis, if therapy >2wks

Answer 1

linezolid

Question 2

HTN due to decreased breakdown of dietary tyr

Answer 2

linezolid

Question 2

crystalline in urinary tract

Answer 2

sulfonamide

Question 3

hemolytic anemia

Answer 3

sulfonamide

Question 4

90% bound to serum albumin

Answer 4

daptomycin

Question 4

contraindicated in PKU

Answer 4

linezolid

Question 4

competes with deoxyCTP

Answer 4

cidofovir

Question 5

metabolized to penciclovir

Answer 5

famciclovir

Question 7

nephrotoxicity

Answer 7

cidofovir

Question 9

Bacitracin MOA

Answer 9

inhibits wall synth by inhibiting phosphorylation of isoprenyl pyrophosphate carrier protein **no movement of peptidoglycan from inside to outside of mem

Question 9

causes muscle toxicity if given IM

Answer 9

daptomycin

Question 10

neurotoxicity, incl seizures

Answer 10

acyclovir valacyclovir

Question 10

chelates Ca++

Answer 10

foscarnet

Question 11

antagonizes surfactant = not for trx of pneumonia

Answer 11

daptomycin

Question 11

inherently active

Answer 11

cidofovir foscarnet

Question 11

blocks chain elongation

Answer 11

foscarnet

Question 13

causes electrolyte imbalance

Answer 13

foscarnet

Question 14

inhibits monoamine oxidase

Answer 14

linezolid

Question 16

Contraindicated if heme disease or folic acid deficiency

Answer 16

bactrim

Question 17

prodrug for acyclovir

Answer 17

valacyclovir

Question 18

cross hypersensivity:

Answer 18

*acyclo, *famciclo, ganciclo, *valacyclo, valaganciclo

Question 19

peripheral neuropathy

Answer 19

linezolid

Question 21

concurrent probenecid

Answer 21

cidofovir

Question 23

muscle pain and weakness

Answer 23

daptomycin

Question 24

Bactrim MOA

Answer 24

sulfonamide: inhibits PABA for folic acid synthesis trimethoprim: inhibits DHFR (highly selective for bacterial enzyme)

Question 24

selectively inhibits viral DNA-pol and rev transcriptase at pyrophosphate binding site

Answer 24

foscarnet

Question 25

distributed to all tissues

Answer 25

bactrim

Question 26

contraindicated in crohn's disease

Answer 26

sulfonamide

Question 27

Causes -penia's

Answer 27

ganciclovir

Question 28

NVD, possible psudomembranous colitis

Answer 28

linezolid

Question 30

optic neuropathy

Answer 30

linezolid

Question 31

increases protein bound drugs, like warfarin

Answer 31

sulfonamide

Question 33

use with statins cautioned

Answer 33

daptomycin

Question 34

metabolized into 2 inactive metabolites

Answer 34

linezolid

Question 35

Renal failure, due to PEG

Answer 35

bacitracin

Question 36

Myelosuppression, reversible neutropenia/anemia/thrombocytopenia

Answer 36

linezolid

Question 37

Mupirocin MOA

Answer 37

reversibly binds to staph isoleucyl tRNA synthetase

Question 39

increased reaction in HIV patients

Answer 39

bactrim

Question 40

Daptomycin MOA

Answer 40

disrupts cell membrane =\> depolarizes =\> loss of mem potential and K efflux

Question 41

teratogenic

Answer 41

valacyclovir