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Derm Pharm > Abx, Antivirals > Flashcards

Abx, Antivirals Flashcards

1
Q

Linezolid MOA

A

blocks protein synthesis by binding 23S RNA on ribosome subunit

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1
Q

lactic acidosis, if therapy >2wks

A

linezolid

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2
Q

HTN due to decreased breakdown of dietary tyr

A

linezolid

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2
Q

crystalline in urinary tract

A

sulfonamide

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3
Q

hemolytic anemia

A

sulfonamide

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4
Q

90% bound to serum albumin

A

daptomycin

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4
Q

contraindicated in PKU

A

linezolid

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4
Q

competes with deoxyCTP

A

cidofovir

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5
Q

metabolized to penciclovir

A

famciclovir

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7
Q

nephrotoxicity

A

cidofovir

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9
Q

Bacitracin MOA

A

inhibits wall synth by inhibiting phosphorylation of isoprenyl pyrophosphate carrier protein **no movement of peptidoglycan from inside to outside of mem

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9
Q

causes muscle toxicity if given IM

A

daptomycin

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10
Q

neurotoxicity, incl seizures

A

acyclovir valacyclovir

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10
Q

chelates Ca++

A

foscarnet

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11
Q

antagonizes surfactant = not for trx of pneumonia

A

daptomycin

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11
Q

inherently active

A

cidofovir foscarnet

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11
Q

blocks chain elongation

13
Q

causes electrolyte imbalance

14
Q

inhibits monoamine oxidase

16
Q

Contraindicated if heme disease or folic acid deficiency

17
Q

prodrug for acyclovir

A

valacyclovir

18
Q

cross hypersensivity:

A

*acyclo, *famciclo, ganciclo, *valacyclo, valaganciclo

19
Q

peripheral neuropathy

21
Q

concurrent probenecid

23
Q

muscle pain and weakness

A

daptomycin

24
Q

Bactrim MOA

A

sulfonamide: inhibits PABA for folic acid synthesis trimethoprim: inhibits DHFR (highly selective for bacterial enzyme)

24
Q

selectively inhibits viral DNA-pol and rev transcriptase at pyrophosphate binding site

25
Q

distributed to all tissues

26
Q

contraindicated in crohn’s disease

A

sulfonamide

27
Q

Causes -penia’s

A

ganciclovir

28
Q

NVD, possible psudomembranous colitis

30
Q

optic neuropathy

31
Q

increases protein bound drugs, like warfarin

A

sulfonamide

33
Q

use with statins cautioned

A

daptomycin

34
Q

metabolized into 2 inactive metabolites

35
Q

Renal failure, due to PEG

A

bacitracin

36
Q

Myelosuppression, reversible neutropenia/anemia/thrombocytopenia

37
Q

Mupirocin MOA

A

reversibly binds to staph isoleucyl tRNA synthetase

39
Q

increased reaction in HIV patients

40
Q

Daptomycin MOA

A

disrupts cell membrane => depolarizes => loss of mem potential and K efflux

41
Q

teratogenic

A

valacyclovir

Derm Pharm (5 decks)

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