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Pharmacology > Skeletal Muscle Relaxants > Flashcards

Skeletal Muscle Relaxants Flashcards

1
Q

What are the modes of elimitation of nondepolarizing neuromuscular blockers?

A

Acetylcholinesterase: mivacuriom
Bile: vecuronium
Renal: PPMT - pancuronium, pipecuronium, metocurine, tubocurarine

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2
Q

Which drug has the most rapid onset time?

A

Rocuronium

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3
Q

What are the drugs used in lethal injection?

A

PPT
Pancuronium, 100mg
Potassium chloride, 100mEq
Thiopental, 5g

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4
Q

What is the other name for succinylcholine?

A

Succinyl choline

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5
Q

What is the MOA of succinylcholine?

A

ACh-N agonist -> persistent depolarization -> flaccid paralysis

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6
Q

What is the cause of malignant hyperthermia?

A

Interaction of succinylcholine and inhaled anesthetics

Massive calcium release

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7
Q

How do you manage malignant hyperthermia?

A

Cooling

Dantrolene

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8
Q

What is the MOA of Baclofen?

A

GABA-B agonist: spinal inhibition of motor neurons

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9
Q

What is the MOA of Dantrolene?

A

Blocks RyR1 Ca2+ release channels

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Pharmacology (8 decks)

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