Basic Principles of Pharmacology

Question 1

Differentiate pharmacokinetics from pharmacodynamics

Answer 1

Pharmacokinetics: actions of the body on a drug - absorption, distribution, metqboliwm, excretion
Pharmacodynamics: actions of the drug on th body - receptors interactions, dose-response phenomena, mechanisms of therapeutic and toxic actions

Question 2

What are intert binding sites?

Answer 2

Nonregulatory molecules that do not produce discernible effects
Buffer the concentration of a drug because bound drug does not contribute to the concentration gradient

Question 3

What is Fick’s Law of Diffusion?

Answer 3

It predicts the rte of movement of molecules across a barrier

Question 4

What are the drug receptor bonds in decreasing order of strength?

Answer 4

Covalent bonds
Hydrogen bonds, Ionic bonds, Van der Waals bond
Hydrophobic bonding

Question 5

What is permeation?

Answer 5

It is the movement of drug molecules into and within biologic environments

Question 6

What are the drugs that follow zero order kinetics?

Answer 6

WHAT PET
Warfarin
Heparin
Aspirin
Tolbutamide
Phenytoin
Ethanol
Theophylline