Antiseizure Drugs Flashcards
What are the common drugs used for tonic-clonic seizures?
CLP-V Carbamazepine Lamotrigine Phenytoin Valproic acid
What are the common drugs used in absence seizure?
CEV
Clonazepam
Ethosuximide
Valproic acid
What are the common drugs used in myoclonic seizure?
LV-C
Lamotrigine
Valproic acid
Clonazepam
What are the features of simple partial seizure?
CPAP Convulsive jerking Paresthesias Autonomic dysfunction Psychic symptoms: altered sensory perception, illusions, hallucinations, affect changes
What are the features of general tonic-clonic seizure?
Tonic (<1min): loss of consciousness, muscle rigidity, respiration arrest
Clonic (2-3mins): muscle jerking, lip/tongue biting, fecal/urinary incontinence
What are the available hydrantoin anticonvulsant drugs?
PE-FM Phenytoin Ethotoin Fosfophenytoin Mephenytoin
What is the MOA of hydrantoin and tricyclic anticonvulsant drugs?
Blocks voltage-gated Na channels
What are the features of fetal hydrantoin syndrome?
M-U-L-L Midfacial hypoplasia Upturned nose Long upper lip with thin vermillon border Lower distal digital hypoplasia
What is the DOC for trigeminal neuralgia?
Carbamazepine
This drug used in general tonic-clonic seizure is also used as a drug of choice for what?
Bipolar disorder, acute mania
What are the available cyclic ureide anticonvulsant drugs available? What is their MOA?
PEM
Phensuximide
Ethosuximide
Methsuximide
MOA: decreases T-type calcium currents inteh thalamus
What are clinical uses of gabapentin?
PMN
Partial seizures
Migraines
Neuropathic pain
Pregabalin is combined with what drug for neuropathic pain?
Methylcobalamin
What is the MOA of lamotrigine?
Blocks Na and Ca chanels
Decrease glutamate
What are the SE of zonisamide?
CCP
Cognitive impairment
Confusion
Poor concentration
