Skeletal muscle relaxants

Question 1

Spasm

Answer 1

Muscle damage = long lasting muscle contraction

Question 2

Spasticity

Answer 2

Neuronal CNS or spinal

Muscle in shortened position for longer time

Question 3

Tonic somatic motor activity influencing both alpha and gamma motor neurons

Answer 3

Cyclobenzaprine

Question 4

Anticholinergic spasmolytic

Answer 4

Orphenadrine

Question 5

Spasmolytic good for lumbargo and sciatica

Answer 5

Orphenadrine

Question 6

Spasmolytics action

Answer 6

depress polysnaptic reflexes > monosynaptic

Question 7

Spasmolytic with longest half life and duration

Answer 7

Cyclobenzaprine

Question 8

Spasmolytic similar to TCA

Answer 8

Cyclobenzaprine

Question 9

Which spasmolytic causes areflexia, flaccid paralysis at high doses

Answer 9

Cyclobenzaprine

Question 10

Which spasmolytic causes discolored urine at low dose?

Answer 10

Methocarbamol

Question 11

Which spasmolytic can be used parenterally?

Answer 11

Methocarbamol

Question 12

Which antispasmodic can be used to treat hiccups?

Answer 12

Baclofen

Question 13

Which antispasmodic can be used for trigeminal neuralgia or neuropathic pain?

Answer 13

Baclofen

Question 14

Which antispasmodic can be used intrathecally?

Answer 14

Baclofen

Question 15

Which acts on GABAb receptor?

Answer 15

Baclofen

Question 16

Binding to pre-synaptic GABAb

Answer 16

Ca influx inhibited

No release of glutamate or aspartate (excitatory)

Question 17

Binding to post-synaptic GABAb

Answer 17

Activate K channel second messenger Arachidonic acid, prevent Substance P release (pain)

Question 18

Act on A-2 Adrenergic

Answer 18

Tizanidine

Question 19

Which causes elevation of liver enzymes

Answer 19

Tizanidine

Question 20

Treats dystonia

Answer 20

Botox

Question 21

Treats hyperhidrosis

Answer 21

Botox

Question 22

Inhibit ACH release from terminals causing chemodenervation

Answer 22

Botox

Question 23

How long does muscle paralysis last with botox

Answer 23

12-16 weeks

Question 24

Precaution with botox:

Answer 24

Toxin that does not stay contained can results in muscle paralysis in unintentional area

Question 25

Targets GABAa receptor

Answer 25

Diazepam

Question 26

Used as adjunct with Baclofen

Answer 26

Diazepam

Question 27

GABAa receptor effect on pre-synaptic neuron

Answer 27

increase chloride conduction (inhibition/hyperpolarization) of pre-synaptic

Question 28

Which drug is muscle acting?

Answer 28

Dantrolene sodium

Question 29

Which is used to treat malignant hyperthermia?

Answer 29

Dantrolene sodium

Question 30

Only drug known to treat neuroleptic malignant syndrome (defect in ryanodine receptor in SR)

Answer 30

Dantrolene sodium

Question 31

Not used in ALS

Answer 31

Dantrolene sodium

Question 32

Which drug has the highest likelihood of addiction?

Answer 32

Cyclobenzaprine

Question 33

Which drug has compliance issues due to common side effect of diarrhea?

Answer 33

Dantrolene sodium

Question 34

Which drug cannot be used with HTN medication?

Answer 34

Tizanidine (A-2 receptor mechanism crossover)

Question 35

Which can cause hepatotoxicity?

Answer 35

Dantrolene Sodium