Chemotherapy

Question 1

Anti-alkylating agent

Answer 1

Cyclophosphamide

Question 2

Cyclophosphamide MOA

Answer 2

highly reactive drug metabolite that binds to DNA making it inactive and initiates apoptosis

Question 3

Antimetabolite

Answer 3

Methotrexate

Question 4

Antimetabolite MOA

Answer 4

analog of endogenous precursors of DNA and RNA prevent nucleic acid synthesis
Target the S phase

Question 5

Methotrexate blocks

Answer 5

dihydrofolate reductase

folic acid analog

Question 6

Antitumor antibiotic

Answer 6

Doxorubicin

Question 7

Which drug is associated with cardiotoxicity and myocardial damage?

Answer 7

Doxorubicin

Question 8

Doxorubicin MOA

Answer 8

insertion between DNA base pairs

non-specific to cell cycle

Question 9

Mitotic spindle inhibitors

Answer 9

Vincristine and Paclitaxel

Question 10

Topoisomerase inhibitors

Answer 10

Irinotecan

Question 11

Irinotecan MOA

Answer 11

Inhibit toposiomerase from cleaving and reassembling DNA

S phase specific

Question 12

Rituximab

Answer 12

Ab targeted for NHL CD20

Question 13

Trastizumab

Answer 13

Target HER-2 in Breast cancer

Question 14

Tyrosine kinase inhibitor

Answer 14

Imatinib (Gleevec)

Question 15

Imatinib MOA

Answer 15

inhibits tyrosine kinase expression in philadelphia chromosome in CML inducing apoptosis

Question 16

Side effects of chemo:

Answer 16

Myelosuppression
stomatitis 
diarrhea 
alopecia secondary tumor
N/V