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Cell Physiology > Skeletal Muscle and Sliding Filament Theory > Flashcards

Skeletal Muscle and Sliding Filament Theory Flashcards

1
Q

What microfilaments are in the I band?

A

Actin only

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2
Q

What is actin composed of?

A

F-actin, tropomyosin, and troponin

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3
Q

What is F-actin?

A

Binding sites for myosin

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4
Q

What is the function of tropomyosin in the actin filament?

A

Stabilizes and stiffens the filament
Covers the binding sites for myosin

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5
Q

What is the function of troponin in the actin filament?

A

When bound to calcium, troponin causes a conformational change that forces tropomyosin into the groove and allows cross bridge formation.

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6
Q

What is the function of troponin I?

A

Binds to actin

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7
Q

What is the location of troponin T?

A

At the end of tropomyosin

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8
Q

What is the function of troponin C?

A

Binds calcium

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9
Q

What is the A band? What microfilaments does it contain?

A

The length of myosin
Contains myosin and actin

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10
Q

What microfilaments are in the H zone?

A

Myosin only

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11
Q

Which sections of the sarcomere decrease when muscle is contracted?

A

Both H zone and I band

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12
Q

When muscle is contracted, which section of the sarcomere does not change in length?

A

A band

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13
Q

What is the structure of myosin?

A

Myosin tails of two heavy chains and myosin heads of four light chains containing ATPase activity

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14
Q

Describe the location of the accessory protein nebulin.

A

Adjacent to the actin filaments and attaching to the Z line

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15
Q

Describe the accessory protein titin.

A

Titin is an elastic protein that attaches the ends of the myosin molecule to the Z line

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16
Q

What occurs during the relaxed state of sliding filament theory?

A

ATP is bound to the myosin head

17
Q

What occurs during cross bridge formation of sliding filament theory?

A

ATPase converts ATP to ADP + Pi. This allows high energy or ready position. If calcium is present, myosin binds to actin.

18
Q

What occurs during the power stroke of sliding filament theory?

A

Release of ADP + Pi, actin slides over myosin

19
Q

What occurs during termination or end of contraction of sliding filament theory?

A

ATP binds to the myosin head and calcium is pumped out of cell and back into sarcoplasmic reticulum.

20
Q

What is the function of sarcoplasmic reticulum?

A

Stores calcium with calsequestrin

21
Q

What are the events of sliding filament theory in order?

A

Relaxed state, cross bridge formation, power stroke, termination or end of contraction.

22
Q

Where is the triad of skeletal muscle?

A

AI junction

23
Q

What does the triad of skeletal muscle consist of?

A

T tubule and two terminal cisternae of sarcoplasmic reticulum

24
Q

What is a T tubule and what does it do?

A

T tubule is sarcolemma and it transmits the action potential

Cell Physiology (8 decks)

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