Cell Adhesion Molecules Flashcards
Structure of a tight junction
Physical barrier at apical border
Junction between cell and cell
Function of a tight junction
Blood brain barrier
Integrity of epithelial cell layer
Structure of adherens junction
Located in apical region of the cells just below the tight junctions
Allows neural tube development
Between cell and cell
Function of adherens junctions
Cytoskeleton contractile actin network
Linker glycoprotein- cadherins
In the absence of calcium, what happens to adherens junctions?
Junctions open and cause dysfunctions such as leaky gut
Structure of desmosomes
Spot junction: cell to cell contact
Function of desmosomes
Maintain epithelium integrity
Cytoskeleton intermediate filaments
Structure of a hemidesmosome
Connects cell to basal lamina
Junction cell to matrix
Function of hemidesmosome
Cytoskeleton intermediate filaments
Structure of extracellular matrix
Main components of connective tissue:
Glycosaminoglycans
Fibrous proteins
Adhesive proteins
extracellular matrix
Structure of glycosaminoglycans
Highly negatively charged sulfates
Important in joints
Contain protein proteoglycans
Bottle brush appearance
extracellular matrix
Function of glycosaminoglycans
Attract Na+
Water is drawn in
Swelling or turgor
Turgor resists tissue compression
extracellular matrix
What are the fibrous proteins and what makes them?
Collagen and elastin are made by fibroblasts
extracellular matrix
Function and structure of collagen
Resistant to shearing
Organized into fibrils
Can be bundled into fibers