Cell Adhesion Molecules Flashcards

1
Q
A
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2
Q

Structure of a tight junction

A

Physical barrier at apical border
Junction between cell and cell

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3
Q

Function of a tight junction

A

Blood brain barrier
Integrity of epithelial cell layer

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4
Q

Structure of adherens junction

A

Located in apical region of the cells just below the tight junctions
Allows neural tube development
Between cell and cell

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5
Q

Function of adherens junctions

A

Cytoskeleton contractile actin network
Linker glycoprotein- cadherins

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6
Q

In the absence of calcium, what happens to adherens junctions?

A

Junctions open and cause dysfunctions such as leaky gut

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7
Q

Structure of desmosomes

A

Spot junction: cell to cell contact

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8
Q

Function of desmosomes

A

Maintain epithelium integrity
Cytoskeleton intermediate filaments

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9
Q

Structure of a hemidesmosome

A

Connects cell to basal lamina
Junction cell to matrix

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10
Q

Function of hemidesmosome

A

Cytoskeleton intermediate filaments

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11
Q

Structure of extracellular matrix

A

Main components of connective tissue:
Glycosaminoglycans
Fibrous proteins
Adhesive proteins

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12
Q

extracellular matrix

Structure of glycosaminoglycans

A

Highly negatively charged sulfates
Important in joints
Contain protein proteoglycans
Bottle brush appearance

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13
Q

extracellular matrix

Function of glycosaminoglycans

A

Attract Na+
Water is drawn in
Swelling or turgor
Turgor resists tissue compression

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14
Q

extracellular matrix

What are the fibrous proteins and what makes them?

A

Collagen and elastin are made by fibroblasts

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15
Q

extracellular matrix

Function and structure of collagen

A

Resistant to shearing
Organized into fibrils
Can be bundled into fibers

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16
Q

extracellular matrix

Function and structure of elastin

A

Found in tissues able to stretch and recoil ie. Blood vessels, skin, lungs
In extracellular space cross-linked

17
Q

Function of adhesive glycoproteins

A

Domains that: act as extracellular glue
Binds to cell surfaces
Interacts with collagen
Binds to proteoglycans