Skeletal connective tissue L5 Flashcards
What is specialised connective tissue characterised by
Dominance of matrix
What are the 3 types of specialised connective tissue?
Cartilage: semisolid matrix (semi-rigid structure), bone: calcified matrix and blood: liquid matrix
What does cartilage consist of?
Cells (chondrocytes) which occurs within spaces in the matrix called lacunae, fibers which is a dense network of collagen and/or elastin fibers and matrix (proteoglycans, ground substance)
What is function of lymphatic system?
to remain normal blood volume and other liquids
What are the 3 cartilage cells?
Mesenchymal cell and chondroblasts and chondrocytes
What is the function of mesenchymal cells?
Differentiate into chondroblasts
What are the 5 steps of cartilage formation:
- Chondrification - genesis. Mesenchymal cells differentiate chondroblast
- Chondroblasts proliferate and synthesise ground substance and fibrous extracellular matrix
- Chondroblasts separate into spaces (lacunae)
- More divisions form clusters (isogenous gaps)
- These chondrocytes are embedded in extracellular matrix
What must you remember in regards to B and C
B BEFORE C = chondroBlasts before chondroCytes
What is ossification?
When cartilage is replaced by bone in the body
What are the 2 methods of growth in cartilage?
Appositional growth and interstitial tissue growth
What is interstitial tissue growth?
Increasing in LENGTH; specific for endochondral bone formation; chondrocytes divide and secrete matrix from
within their lacunae
How many bones in an adult?
206 bones
How many bones in infants?
About 300
What are the 8 bone functions?
- Support
- Movement
- Protection
- Hematopoiesis
- Mineral storage
- Acid-base balance
- Detoxification
- Sound transduction
What is hematopoiesis?
Makes red blood cells in red bone marrow
What is the mineral storage in bone?
Acts as a calcium reservoir, maintaining calcium and phosphorus equilibrium
What does the acid-base balance do in bone?
Buffers blood against excessive pH changed by absorbing or releasing alkaline salts
What does the function of detoxification do in bone?
Stores heavy metals and foreign elements.
What is sound transduction?
In mechanical aspect of hearing
What are the 2 types of bone? HINT C+C
Cortical/compact bone and Cancellous/Trabecular/Spongy bone
What % of skeletal mass is cortical bone?
80%
What is the physical description of cortical bone?
Dense protective shell
What is the location of cortical bone?
Around all bones, beneath periosteum. Primarily in the shafts of long bones
What % of skeletal mass is cancellous bone?
20%
What is the function of the periosteum?
Periosteum’s function is to nourishes the bone, it is rich in nutrients and capillaries.
What is the location of the cancellous bone?
In the vertebra, flat bones for example the pelvis and the ends of long bones
What is the physical description of cancellous bone?
Rigid lattice designed for strength; Interstices are
filled with marrow
What can osteoprogenitor cells do?
Osteoprogenitor cells means it can divide and make new cells
What are the 4 types of bone cells?
Osteoprogenitor cells, osteoblasts, osteocytes and osteoclasts
What is the function of osteoprogenitor cells?
Form bone stem cells and make osteoblasts and osteocytes
What is the function of osteoblasts?
They are bone forming cells and immature bone cells that have lots of rough ER for collagen synthesis
What is the function of osteocytes?
Act as inactive osteoblasts and they are the most abundant cell found in bone
What is the function of osteoclasts?
They are phagocytic cells that erode bone and bone resorption and remodelling
What happens at bone fractures?
When a bone fractures a blood clot forms at fracture site (6-8h) and this is replaced by collagen tissue. Then chondroblasts lay down cartilage (provisional callus) (2-3 weeks). Osteoblasts then lay down woven bone
(bony callus) (3-4 months). This bony callus then remodelled to mature lamellar bone
What are the 5 types of fractures?
Simple, stress, comminuted, greenstick, compound/impacted
What are the 2 types of ossification/osteogenesis?
Intramembranous ossification and endochondral ossification
Where is 99% of the body’s Ca^2+ ?
In bone approx 1kg
What is ossification/osteogenesis?
Modelling bone
What are the 2 Ca^2+ compartments?
Bone fluid and Mineralised bone
What happens in the bone fluid Calcium compartment?
Fast exchange of calcium by pumps
What happens in the mineralised bone compartment of Calcium?
There is a slow exchange by bone resorption and osteoclasts phagocytic activity is increased and the Calcium ions are released during low Ca^2+ levels
Greenstisck happens a lot in children, where 1 side of bone is broken and other part is not