Sjogrens syndrome Flashcards
1
Q
definition
A
chronic autoimmune inflammatory disorder which is characterised by diminished lacrimal and salivary gland function causing dry eyes and a dry mouth
2
Q
when does secondary sjogrens occur
A
in rheumatoid arthritis
3
Q
who is sjogrens more common in
A
woman in their 50s and 60s
4
Q
pathophysiology
A
lymphocytic infiltration of exocrine glands results in their fibrosis and destruction
5
Q
what are people who have sjogrens at a much higher risk of
A
NON- HODGKINS LYMPHOMA DUE TO THE CONSTANT STIMULATION OF B CELLS
6
Q
presentation
A
- dry gritty eyes
- dry mouth
- bilateral parotid gland swelling
- vaginal dryness
- arthralgia
- raynauds
- vasculitis
- lung, liver and kidney involvement
7
Q
medical term for dry eyes
A
keratoconjunctivitis sicca
8
Q
medical term for dry mouth
A
xerostomia
9
Q
investigations
A
- shimmers test
- ANTI-RO and ANTI-LA antibodies
- if above tests are negative but still high clinical suspicion you can do an ultrasound guided biopsy of salivary glands
10
Q
management
A
- artificial tears
- punctual plugs in lacrimal glands
- hydroxochloroquine for arthralgia
- methotrexate if any organ involvement
