EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITS

Question 1

previously called

Answer 1

churg- strauss syndrome

Question 2

definition

Answer 2

auto-immune inflammatory systemic disease that is always associated with asthma and esopniophilia, associated with p-ANCA and MPO

Question 3

if they don’t have asthma or eosinophilia then

Answer 3

they DONT HAVE EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS

Question 4

classical triad

Answer 4

1. adult onset asthma
2. eosinophilia greater than 10%
3. vasculitis

Question 5

presentation

Answer 5

asthma, chronic sinusitis, glomerulonephritis, abdominal pain, mononeuritis multiplex, peripheral neuropathies

Question 6

what do you not do on initial suspicion of eosinophilic granulomatosis with polyangiitis

Answer 6

get a p-ANCA titre as its not very sensitive compared to what it is in MPA

Question 7

what is the diagnostic test

Answer 7

biopsy which shows eosinophils in granuloma

Question 8

management

Answer 8

IV STEROIDS AND CYCLOPHOSPHAMIDE

Question 9

what is there a risk off in eosinophilic granulomatosis with polyangiits

Answer 9

coronary disease (aneurysms, MI) so keep blood pressure and lipid levels well under control