Sjogrens Syndrome Flashcards
If Sjogrens diagnosed what test do we want
Baseline MRI
Define Sjogrens syndrome
Autoimmune disease where body’s immune system mistakenly attacks its own salivary+tear glands
Aetiology of Sjogrens
Unknown
Genetic/immune
Can be linked to: RA/lupus
Symptoms of sjogrens
Dry mouth difficulty with speech/swallowing/eating
Altered taste/oral discomfort
Swollen salivary glands around ears or under jaw
DENTALLY:
Increased risk of decay/gingivitis/infections
Reduced denture retention
Inc risk of lymphoma 5%
DRY EYES:
irritable + gritty
T cell function in Sjogrens
Autoimmune process mediated by T lymphocyte destruction
How is Sjogrens diagnosed
Symptoms, exam + further testing
Dry eyes/mouth - >3mths
Unstimulated salivary flow <1.5ml in 15mins
Bloods - antiRo antiLa
US scan of major salivary glands
Labial gland biopsy
Diagnosis is made after tests show you meet the criteria laid out by AECG (4 to qualify)
Tx for Sjogrens
Baseline MRI required - lymphoma risk
Stimulate saliva - sugar free gum/pilocarpine - side effects sweating/tacchycardia
OH: CHX, increased caries prev F toothpaste.FV antifungals if oral infections
Specialist - further tx
Frequent sips of water
Avoid smoking
Keep on top of oH, take denture out, high F
Choose wet foods, diet low in sugar + fizzy drinks
Contact specialist if you notice new symptoms
Sjogrens classification
Partial - sicca syndrome (dry eyes/mouth)
Primary - no connective tissue disease
Secondary - connective tissue disease (RA)
Histology findings for Sjogrens
Lymphocytic foci >50 from biopsy
Acing loss
Myoepithelial islands
Duct hyperplasia
Sialography findings
Snow sort leopard spot appearance
AECG classification (4)
Dry eyes/mouth - unstimulated flow + schemer
Anti Ro/La antibodies
US imaging
Histopathology - foci
