SIRS/Shock - Bowden

Question 1

What is SIRS? 1

Answer 1

Systemic Inflammatory Response Syndrome

Pathogenic overstimulation of the immune response

Question 2

What can contribute to SIRS? 2

Answer 2

Pancreatitis

Trauma

Burns

Surgery

SuperAgs

Question 3

How does our body try to compensate for SIRS? 3

Answer 3

Pt’s body tries to induce CARS - compensatory anti-inflammatory response

Fluctuation between immunosuppressed and hyperactivation with smaller and smaller fluctuations until homeostasis is achieved

Question 4

What are the qualifiers for someone to be said to have SIRS? 4

Answer 4

HR –> >90 bpm

Resp –»20 bpm

Temp –> >38 C or <36 C

Question 5

What makes up sepsis? 4

Answer 5

SIRS + infection

Question 6

In terms of infectious agent, what is the difference between DAMPs and PAMPs? 5

Answer 6

PAMPs - infectious, pathogenic

DAMPs - sterile

Question 7

What is the sensor of the inflammasome? 7

Answer 7

NLRP-3

Question 8

Read 7

Answer 8

Add

Question 9

What is disseminated intravascular clotting?

Answer 9

DIC

Caused by TNF secretion and DAMPs/PAMPs activating TLRs

Question 10

What organs are most susceptible to Disseminated Intravascular Clotting (DIC)?

Answer 10

Lungs

Liver

Kidneys

Question 11

What is Sepsis Associated Encephalopathy (SAE)?

Answer 11

Cerebral dysfunction due to SIRS (systemic inflammatory response)

Question 12

What’s happening in Acute Respiratory Distress Syndrome (ARDS)

Answer 12

Add

Question 13

What are cellular/molecular elements occurring during Compensatory anti-inflammatory response (CARS)?

Answer 13

Lymphocyte dysfunction/apoptosis

ADD!

Question 14

What cytokines are problematic in SIRS or Sepsis? What’s the order of their activation?

Answer 14

C5a –> TNF –> IL-1 –> IL-6