Mechanisms Of Hypersensitivity Type II - Bowden (Completed)

Question 1

What mediates type II hypersensitivity? 23

Answer 1

Antibody mediated: IgG & IgM

effector cells bind to Fc region

Question 2

What kind of damage do we see in type 2 hypersensitivities? 23

Answer 2

Localized damage specific to tissues bearing the antigen

Question 3

What occurs in penicillin hypersensitivity? 25

Answer 3

A type 2 hypersensitivity

Penicillin (hapten) binds erythrocytes (carrier)

This epitope stimulates the production of IgG and IgM

Question 4

What happens if there is a transfusion of incorrectly matched blood? 26

Answer 4

IgM causes agglutination

Complement activation

Intravascular hemolysis

Reactions are immediate

Question 5

In Hemolytic diseases of the newborn (HDNB) what molecule is the focus and what’s happening? 27

Answer 5

Mom Rh- | Baby Rh+

During delivery Rh+ blood leaks into mom’s supply, memory formed

Mom undergoes class switch specific to Rh+ from IgM to IgG

IgG is able to cross placenta and will bind and attack fetal erythrocytes

Question 6

What medication is used to treat fetal Rh+ rejection? 28

Answer 6

Rhogam - monoclonal Ab

Binds Rh (RhD > K Ag) and stops mom from sensitizing to the Ag

Question 7

What therapeutics are used in type II hypersensitivities? 30

Answer 7

Monoclonal:

Anti-CD20 (rituximab)

Anti-CD52 (alemtuzumab)

Question 8

Slide 30

Answer 8

Add

Question 9

What are the major diseases associated with type II Hypersensitivity? 29

Answer 9

Graves Disease (hyperthyroidism)

Rheumatic Fever

Myashtenia gravis ( (-) acetylcholine receptor)

Pernicious anemia

Question 10

What does Anti-CD20 treat? 30

Answer 10

B cell non-hodgkins lymphomas

Question 11

What does anti-CD52 treat? 30

Answer 11

B and T cells with chronic B and T leukemias