SIM Renal Failure Flashcards
How do you determine if someone has intrinsic vs. pre-renal vs. post-renal failure?
It is intrinsic if there is no evidence of the other two (pre or post)
What is pre-renal failure?
Reduced blood flow to kidneys
What is post-renal failure?
Obstruction of urine flow
What tells us the patient didn’t have chronic renal failure?
She had a normal Cr 1 month ago.
She has few risk factors for CKD (only age, HTN)
What tells us the patient likely has acute renal failure?
Normal HCT, absence of renal cortical thinning on CT, oliguria, timing
What is the DDX for intrinsic renal disease?
- Glomerulonephritis
- Interstitial nephritis
- Tubular disease
- Vascular disease
What findings are consistent with a tubulointersitial process?
- Proteinuria
- Pyuria
- Casts
What do patients with glomerulonephritis usually have in their urine?
- Red cells
- Red cell casts
What is interstitial nephritis characterized by?
Inflammation & scarring of tubules & interstitial spaces with sparing of glomeruli and vasculature
What are the three categories of interstitial nephritis?
- Immune-mediated
- Infection-mediated
- Idiopathic
What are examples of immune-mediated interstitial nephritis?
- Drug hypersensitiivity
- W/Glomerulonephritis
- W/out Glomerulonephritis
What immune-mediated interstitial nephritis includes glomerulonephritis?
Lupus
IgA nephropathy
What immune-mediated interstitial nephritis doesn’t include glomerulonephritis?
Sarcoid, Sjogren’s, Transplant rejection
What are examples of Infection-mediated interstitial nephritis?
- Pyelonephritis
- Post-infectious
- Granulomatous disease
What are examples of post-infection interstitial nephritis?
Streptococci, staphylococci, diphtheria, legionella, yersinia, leptospira, mycobacterium, mycoplasma, rickettsia, syphilis, toxoplasmosis, and numerous viruses (EBV, HIV, CMV)