PBL Objectives 2 Flashcards
What is a good Ddx for HSP?
- Idiopathic thrombocytopenic purport (ITP)
- Hypersensitivity vasculitis
- Wegener granulomatosis
- Systemic lupus erythematosus (SLE)
- Rheumatoid arthritis
- Rheumatic fever
- Hemolytic uremic syndrome (HUS)
- Polyarteritis nodosa
- IgA Nephropathy (Berger’s)
Why wasn’t this case Polyarteritis nodosa?
May have similar clinical features to HSP, but uncommon in children
Why wasn’t this case Hemolytic uremic syndrome (HUS)?
- May have similar clinical features
- Rash may also have petechiae
- Diarrhea is common in HUS
What lab findings are found in HUS?
- Hemolytic anemia w/ elevated reticulocyte counts, low haptoglobin levels, low platelets
- Stool studies may be helpful in HUS (these studies are normal in HSP and abnormal in HUS)
Why wasn’t this case Rheumatic fever?
- May have similar clinical features to HSP
- Rash in rheumatic fever is erthrma marginatum and not palpable purpura
What lab values are found in HSP and Rheumatic fever?
Increased antistreptolysin-O antibody titers have been reported in both diseases –> making them difficult to distinguish
Why wasn’t this case Rheumatoid arthritis?
- Similar clinical features to HSP
- However, if rash is present in rheumatoid arthritis it is usually not palpable purpura
- RA is seen more often in adults
What lab values are seen in RA and HSP?
Rheumatoid factor has been reported in both –> difficult to distinguish
Why wasn’t this case SLE?
May have similar clinical features to HSP but uncommon in children
What lab findings can help distinguish SLE from HSP?
- Antinuclear antibodies
- Antineutrophil cytoplasmic antibodies
- Complement levels
Why wasn’t this case Wegener granulomatosis?
Similar clinical features to HSP, but uncommon in children
What lab findings can help distinguish Wegener’s from HSP?
- Antinuclear antibodies
- Antineutrophil cytoplasmic antibodies (c-ANCA)
- Complement levels
Why wasn’t this case Hypersensitivity vasculitis?
Hypersensitivity vasculitis shows NO renal involvement
What lab findings help distinguish HSP from hypersensitivity vasculitis?
-Skin biopsy may show Leukocytoclastic vasculitis, but NO IgA
Why wasn’t this case Idiopathic thrombocytopenic Purport (ITP)?
Rash of ITP may also have petechiae
-Arthralgias and abdominal pain are uncommon
What lab findings help distinguish ITP from HSP?
-Platelet levels are low in ITP, but normal in HSP
What is the major difference between genetic association studies and GWAS studies?
- Genetic association implies that one gene or a few is being looked at
- GWAS is massive amounts of data
What are genetic association studies and GWAS both limited by?
The influence of rare associations that might impact the phenotype
What does linkage analysis require?
Family members!
Why isn’t linkage analysis used for HSP studies?
HSP is so loosely linked to family members so it would be hard to get enough to study that way