Sigdel2

Question 1

In epididymis. Forms abscesses

Answer 1

Gonorrhea

Question 2

Seen in teenagers and adults. Heavy mononuclear (lymphocyte) infiltration. Edema. Neutrophils and abscesses

Answer 2

Mumps

Question 3

Testis involved first, then spreads to epididymis. Perivascular cuffing

Answer 3

Syphilis

Question 4

Gummas (diffuse inflammation of lymphocytes)

Answer 4

Syphilis

Question 5

Non specific, chronic inflammation

Answer 5

Chronic orchitis

Question 6

Rises in epididymis then moves to testis. Caseating granulomas

Answer 6

TB

Question 7

Twisting of spermatic cord, blocking venous drainage. Causes hemorrhagic infarction. Medical emergency

Answer 7

Torsion

Question 8

Benign. Arises in epididymis. Mesothelial in nature. Accurate diagnosis early will spare orchiectomy. Treat by simple excision

Answer 8

Benign paratesticular tumor - adenomatoid tumor

Question 9

Increased hyaline deposition. Failure of germ cell maturation. Increased leydig cells. Tubular atrophy increases with age

Answer 9

Cryptochid testes

Question 10

Similar to CIS. Leads to invasive tumors. Most germ cell tumors arise from this. Isochromosome 12p

Answer 10

Intratubular germ cell neoplasia

Question 11

More aggressive tumors, but respond to therapy. Peak age 15-34 and 60+. Presents as painless testicular mass. Associated with testicular dysgenesis syndrome (cryptorchidism, hypospadias, and poor sperm quality)

Answer 11

Germ cell tumors

Question 12

Usually benign

Answer 12

Sex cord (stromal) tumors

Question 13

Isochromosome 12p. OCT3/4, NANOG, KIT activating mutation

Answer 13

Germ cell tumors

Question 14

Staging is most predictive of prognosis with

Answer 14

Germ cell tumors

Question 15

Alpha fetal protein elevated in

Answer 15

Yolk sac tumors

Question 16

HCG elevated in

Answer 16

Choriocarcinoma

Question 17

Most common germ cell tumor

Answer 17

Seminoma

Question 18

Rare in children. Avg age 30. Confined to testes at presentation. Preceded by ITGCN. Very radiosensitive. PLAP +. Golden, fleshy looking

Answer 18

Seminoma

Question 19

Lobules with thin septa, large cells, sparse lymphocytes

Answer 19

Seminoma

Question 20

Never mixed with other germ cell tumors. PLAP negative.

Seen in older ppl (65+). Excellent prognosis. Diffuse sheets. Has 3 types of cells (small, intermediate, and large)

Answer 20

Spermatocytic seminoma

Question 21

More aggressive than seminomas. 20-30 yr olds. Large, undifferentiated cells. PLAP +

Answer 21

Embryonal carcinoma

Question 22

Pure form in infants and young children. Adults usually have it with Embryonal carcinoma. NOT preceded by ITGCN

Answer 22

Yolk sac tumor

Question 23

+ for alpha fetoprotein. Excellent prognosis with treatment in kids

Answer 23

Yolk sac tumor

Question 24

Central core with endodermal sinus pattern. Schiller-Duvall bodies that resemble primitive glomeruli

Answer 24

Yolk sac tumor

Question 25

Highly malignant. Presents initially as mets to liver/lung. Usually in mixed form. Has hemorrhage and necrosis.

Answer 25

Choriocarcinoma

Question 26

Has Syncytiotrophoblasts and Cytotrophoblasts

Answer 26

Choriocarcinoma

Question 27

Large cells with irregular nuclei

Answer 27

Syncytiotrophoblasts

Question 28

Smaller cells with clear cytoplasm

Answer 28

Cytotrophoblasts