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Exam 12 > Androgens > Flashcards

Androgens Flashcards

1
Q

More lipophilic. Given IM. Longer duration - need to be given every 2/4 weeks

A

Testosterone esters - cypionate and enanthate

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2
Q

Used for hypogonadism and metastatic breast cancer in women

A

Testosterone esters - cypionate and enanthate.

17 alpha-alkylated testosterone.

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3
Q

Orally effective. Methyltestosterone and fluoxymesterone

A

17 alpha-alkylated testosterone

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4
Q

High abuse potential due to anabolic activity

A

17 alpha-alkylated testosterone

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5
Q

Avoid in male Breast cancer, prostate cancer, and pregnancy

A

17 alpha-alkylated testosterone

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6
Q

Low doses will cause cholestatic hepatitis and jaundice

A

17 alpha-alkylated testosterone

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7
Q

Greatest risk of hepatotoxicity

A

17 alpha-alkylated testosterone - methyl testosterone and fluoxymesterone

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8
Q

Can cause edema, liver cancer, and bleeding due to clotting factor deficiencies 2,5,7,10

A

17 alpha-alkylated testosterone - methyltestosterone and fluoxymesterone

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9
Q

Contraindications for all ______ include prostate cancer, pregnancy, and male breast cancer

A

Testosterone analogues

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10
Q

Greatest risk of jaundice

A

17 alpha-alkylated testosterone methyltestosterone and fluoxymesterone

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11
Q

Depresses preovulatory surge of FSH and LH, suppresses mid cycle surge of FSH and LH, reduces ovarian estrogen and progesterone production

A

Danazol

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12
Q

Causes weight gain in women

A

Danazol

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13
Q

Used for endometriosis

A

Danazol

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14
Q

Can cause acne and thrombosis

A

Danazol

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15
Q

Avoid in pregnancy and breast feeding

A

Danazol

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16
Q

Testosterone derivative with strong anabolic action

A

Stanazolol

17
Q

Used for hereditary angioedema

A

Stanazolol

18
Q

Big risk of hepatic toxicity

A

Stanazolol

19
Q

Avoid in pregnancy, male breast or prostate cancer, and female breast cancer with hypercalcemia

A

Stanazolol

20
Q

Testosterone cypionate and enanthate

A

Testosterone esters

21
Q

High anabolic to androgeic ratio. Approved for use of weight gain in pts that had extensive surgery, severe trauma, or long term corticosteroids

A

Oxandrolone

22
Q

Finasteride and dutasteride

A

Antiandrogens

23
Q

Reduce levels of dihydrotestosterone

A

Antiandrogens finasteride and dutasteride

24
Q

Testosterone > DHT by

A

5 alpha-reductase

25
Q

Competitive inhibitor of type 2 5-alpha reductase

A

Finasteride

26
Q

Competitive inhibitor of type 1 and 2 forms 5-alpha reductase

A

Dutasteride

27
Q

Used for BPH. May take 6 months to reduce size of prostate

A

Antiandrogens - finasteride and dutasteride

28
Q

Tamsulosin and alfuzosin

A

Alpha 1 adrenergic inhibitors

29
Q

Decrease smooth muscle tone in prostate and bladder neck

A

Alpha 1 inhibitors tamsulosin and alfuzosin

30
Q

Lower PSA levels by 50%

A

Antiandrogens - finasteride and dutasteride

Exam 12 (11 decks)

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