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Exam 12 > Neuropharm3 > Flashcards

Neuropharm3 Flashcards

1
Q

Lack of ADH

A

Diabetes insipidus

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2
Q

Inadequate ADH releases

A

Central diabetes insipidus

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3
Q

Lack of ability to respond to ADH

A

Nephrogenic diabetes insipidus

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4
Q

Hypercalcemia, hypokalemia, post obstructive renal failure

A

Nephrogenic diabetes insipidus

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5
Q

Treat diabetes insipidus by adjusting

A

Fluid intake

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6
Q

Synthetic analog of vasopressin. Has reduced vasopressor activity, but enhanced anti-diuretic activity compared with vasopressin

A

Desmopressin

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7
Q

Also used for Von-willebrand disease type 1 and primary nocturnal enuresis

A

Desmopressin

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8
Q

Vasopressor activity is due to activation of _______ receptor

A

V1

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9
Q

Facial pallor, increases in GI activity causing nausea and cramps, vasoconstriction of coronary arteries

A

Vasopressin - more prominent than desmopressin effects

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10
Q

Higher activity toward V1 receptor

A

Vasopressin

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11
Q

Overstimulation of ____ receptor in tubules causes water intoxication

A

V2

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12
Q

Chlorpropamide and carbamazepine increase sensitivity of collecting duct to

A

Vasopressin

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13
Q

Lithium and demeclocycline will inhibit ________ on collecting duct

A

Vasopressin

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14
Q

Lithium associated with

A

Nephrogenic diabetes insipidus

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15
Q

Treatment includes adequate water intake (thiazide diuretics and restriction of sodium intake) and amiloride

A

Treatment of Nephrogenic diabetes insipidus

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16
Q

Blocks lithium uptake by Na channel into collecting duct. Used to reverse lithium induced Nephrogenic diabetes insipidus

A

Amiloride

17
Q

Hyponatremia, hypo-osmolality

A

SIADH

18
Q

Can be causes by SSRIs, TCAs, sulfonylureas, vinca alkaloids

A

SIADH

19
Q

Plasma hypotonicity, lethary, anorexia, N/V, muscle cramps, coma, convulsions, and death

A

SIADH

20
Q

Treatment by fluid restriction

A

SIADH

21
Q

V1 and V2 receptor antagonist

A

Conivaptan

22
Q

Selective V2 receptor antagonist

A

Tolvaptan

23
Q

Used for abortion, adjunct, inducing labor, postpartum hemorrhage, and induction of lactation

A

Oxytocin

24
Q

Synthetic oxytocin given IV for

A

Inducing labor

25
Q

Synthetic oxytocin given IM for

A

Controlling post partum hemorrhage

26
Q

Synthetic oxytocin given intranasally for

A

Inducing lactation

27
Q

Overstimulation can cause trauma to mother or fetus, uterine rupture, water intoxication, and allergic rxs

A

Oxytocin

28
Q

Blocks conversion of testosterone to DHT. Prostate tissue shrinks. Used to treat benign BPH

A

5 alpha reductase inhibitor (finasteride)

Exam 12 (11 decks)

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