Neuropharm2

Question 1

Mimics actions of LH. Promotes ovulation in women and external sexual development in males (via increased testosterone production).

Answer 1

HCG

Question 2

Used for simulation of ovulation in anovulatory women and to treat male infertility and cryptorchidism

Answer 2

HCG

Question 3

Human menopausal gonadotropins. Extracted from urine of postmenopausal women

Answer 3

Menotropins

Question 4

Has equal amounts of partially degraded FSH and LH.

Answer 4

Menotropins

Question 5

Given for female infertility to stimulate development of ovarian follicles. Promotes spermatogenesis in males

Answer 5

Menotropins

Question 6

Menotropin preparation from which most of LH has been removed, leaving FSH. Similar indications to Menotropins

Answer 6

Urofollitropin

Question 7

Risk of multiple births, ovarian hyper stimulation. Gynecomastia in men.

Answer 7

Gonadotropin mimics (HSG, Menotropins, Urofollitropins)

Question 8

Estrogen receptor antagonist.

Answer 8

Clomiphene

Question 9

Increases gonadotropin secretion and ovulation

Answer 9

Clomiphene

Question 10

Given for female infertility due to polycystic ovarian syndrome

Answer 10

Clomiphene (estrogen receptor antagonist)

Question 11

Increases LH and FSH by inhibiting estrogen negative feedback at hypothalamus

Answer 11

Clomiphene

Question 12

Side effects > multiple births, antiestrogenic effects on developing follicle, ovarian cysts, endometrium and cervical mucosa

Answer 12

Clomiphene

Question 13

Synthetic human GnRH. Given via pump to mimic endogenous GnRH release

Answer 13

Gonadorelin

Question 14

Placental hormone gotten from urine of pregnant women.

Answer 14

HCG (human chorionic gonadotropin)

Question 15

Leuprolide, goserelin, nafarelin, histrelin

Answer 15

Long acting synthetic GnRH agonists

Question 16

Longer half lives than endogenous GnRH, improved receptor binding affinity. Causes down regulation of GnRH receptor and inhibit gonadotropin secretion. Must be given continuously 2-4 wks to be effective

Answer 16

Long acting GnRH agonists (Leuprolide, goserelin, nafarelin, histrelin)

Question 17

Used in endometriosis, uterine fibroids, advanced prostate cancer, breast cancer, and central precocious puberty

Answer 17

Long acting GnRH agonists

Question 18

Cause hot flashes, decreases in bone density, vaginal dryness and atrophy, erectile dysfunction (b/c of decreased estrogen in women and decreased testosterone in men)

Answer 18

Long acting GnRH agonists

Question 19

Flutamide, bicalutamide

Answer 19

Androgen receptor antagonists

Question 20

Give with long acting GnRH analog for treatment of metastatic prostate cancer

Answer 20

Androgen receptor antagonist

Question 21

Should not be given alone b/c of increases in LH synthesis. Will increase testosterone production

Answer 21

Androgen receptor antagonists

Question 22

May causes reversible liver damage. Liver fn should be assayed prior to and during treatment

Answer 22

Androgen receptor antagonists (Flutamide, bicalutamide)

Question 23

Finasteride

Answer 23

5 alpha reductase inhibitor