Sigdel Flashcards
No 3p alteration
Renal papillary adenoma
Tubule papillary architecture
Renal papillary adenoma
Benign,
Renal fibroma (hamartoma)
Incidental finding. In pyramids
Renal fibroma (hamartoma)
Fibroblast like cells, collage nous tissues, entrapped tubules at periphery
Renal fibroma (hamartoma)
Multiple masses of angiomyolipomas indicate
Tuberous sclerosis
Has spindle and Epitheloid cells
Angiomyolipoma
AD with LOF of tumor suppressor genes (TSC1 on Chr _____ and TSC2 on Chr _____). Also lesions on cerebral cortex, skin abnormalities, other benign tumors
Tuberous sclerosis
9.
16.
Adults > 50. Men. Incidental finding. Usually multifocal. Benign, but may coexist with RCC
Oncocytoma
Mahagony brown tumor. Fibrosis in middle
Oncocytoma
Mostly sporadic. Major risk factor is tobacco. Arises from renal tubular epithelium
RCC
Costovertebral pain, palpable mass, hematuria
RCC
Only treatment is nephrectomy
RCC
Mets to lung and bones
RCC
Most common. Loss of sequences on short am Chr 3 (VHL - tumor suppressor genes). AD. Pancreas, liver, and kidney cysts. Hemangioblasts in retina and cerebellum
Clear cell type RCC
Papillary growth pattern. Multifocal. Associated with dialysis
Papillary RCC
Has schamomma bodies > calcium deposition
Papillary RCC
Sporadic form most common. Trisomies 7,16,17. Loss of Y in males
Papillary RCC
Familial form. Trisomy 7 (has MET locus - protooncogene tyrosine kinase receptor)
Papillary RCC
Prominent cell membrane with nuclear clearing
Chromophobe RCC
Use stain of hale’s colloidal iron (cells stain blue)
Chromophobe RCC
Benign. Incidental finding at autopsy or body imaging. Needs long term hemodialysis.
Renal papillary adenoma
