Random Flashcards
Focal segmental glomerulosclerosis and membranous nephropathy
Nonselective proteinuria
Humps subepithelially
Acute proliferative
Spikes and domes subepithelially
Membranous nephropathy
Sub endothelial tram tracking
Membranoproliferative
Ratio > 20:1
Pre-renal injury
Proton pump inhibitors can cause
Interstitial nephritis
Obstruction can cause
Hyperkalemia
Cysts from tubules all throughout nephron
ADPKD
More common but less progressive
ADPKD
Progressive.
ARPKD
Cysts from collecting ducts
ARPKD
Caused by failure of formation of ureteric bud
Renal agenesis
Causes potter syndrome (Anuria, oligohydramnios, pulmonary hypoplasia)
Potter syndrome - renal agenesis
Wilms tumors gene (WT1) on Chr
11
Aniridia, hemi hypertrophy, Wilms tumor
WAGR
Renal failure, pseduohermaphraditism, Wilms tumor
Denys-drash
1-3 million collecting tubules and ducts, major and minor calyces, renal pelvis, ureters
Ureteric bud
Glomeruli, PCT, loop of henle, DCT, Bowman’s space (parietal layer and podocytes)
Metanephric blastema
Aberrant renal artery obstructs urine flow at
Pelviureteral junction
Horseshoe kidney causes increased risk of
Nephroblastoma (Wilms tumor)
Formed in wk 4 and disappears by wk 5
Pro nephrons
7-10 solid cell groups in cervical region
Pronephros
Forms vestigial excretory units (nephrotomes) that regress when more caudal ones are formed
Pronephros
Wks 3-4. Upper thoracic > L3.
Mesonephros
Forms first excretory tubules in early wk 4 as Pronephros regress
Mesonephros
Forms ductus deferents, ejaculatory duct, epididymis, and seminal vesicle
Mesonephric (Wolfiann duct) in males
Forms vestigial garner’s ducts
Mesonephros in females
At day 28 mesonephric duct >
Ureteric bud
Forms definitive adult kidney from ureteric bud
Metanephros
Ureteric bud penetrates
Sacral intermediate mesoderm (metanephric blastema)
Selective albumin proteinuria
Minimal change