Side-Effects of Common Drugs Here

Question 1

What are the se’s of NSAIDs?

Answer 1

• Dyspepsia and GI ulceration
• Nephrotoxicity - causes afferent arteriole vasoconstriction

Question 2

What are the se’s of Bisphosphonates?

What steps can be done to reduce the risk of the main se’s?

Answer 2

➊ • Oesophageal reactions, such as oesophagitis, oesophageal ulcers, erosions and strictures
• Jaw osteonecrosis
• Hypocalcaemia

➋ • Take whole, with lots of water
• Take on an empty stomach at least 30 mins before breakfast
• After taking, remain upright for at least 30 mins

Question 3

What are the se’s of Corticosteroids?

Answer 3

• Adrenal suppression
• Immunosupression
• Cushingoid appearance - central obesity, buffalo hump, moon face
• Thinning of skin
• Hyperglycaemia
• Acne

Question 4

What are the se’s of Methotrexate?

Answer 4

• GI disturbance
• Folate deficiency (anaemia)
• Immunosupression (causes bone marrow suppression)
• Teratogenicity