Sickle Cell Flashcards
Sickle Cell disease capillary occlusion is now thought to occur by….
Endothelial damage causing multicellular (platelets, white cells) aggregates which occlude the capillary
Where are ribosomes assembled?
Inside the nucleus
In Sickle Cell disease an acute pain crisis is typically caused by capillary occlusion in the …
Bone
In Sickle Cell disease hypoxia causes the abnormal HbS to…
Polymerise
Sickle cell anaemia (HbS) is caused by…
An autosomal recessive inherited condition substituting the valine amino acid in the beta globin chain
Which of the following is defined as ‘A weak attractive interaction between two atoms due fluctuating electrical charges’?
Van der Waals forces
Which enzyme unwinds supercoiled DNA?
Topoisomerase
Which enzyme unzips the double helix?
Helicase
Which enzyme reads DNA strands to create two new strands?
DNA polymerase
Which enzyme repairs damaged bases in DNA?
Glycoslylases
Sickle cell disease can be treated with hydroxyurea because it…..
Increases the synthesis of HbF (Foetal Hb)
In Sickle Cell disease the HbS structural change causes sickling by…
Binding to the cell cytoskeleton, which distorts the normal cell shape into the classic sickle shape.
