SFP: IBD Flashcards
What is the etiology behind inflammatory bowel diseases?
Intestinal immune cascade is triggered/overactivation of enteric immune and inflammatory pathways lead to signs of damage.
What are some environmental factors involved in IBD?
Smoking and use of NSAIDs.
What are some lab findings of IBD?
Anemia, leukocytosis, elevated platelets, elevated CRP/sed rate, WBC in stool.
What are histologic features of IBD?
Chronic active colitis, architectural distortion, mucin depletion, plasma cells, crypts raised above muscularis.
What biologic agents may be used for IBD?
Anti-TNFa agents.
What are the major sites of involvement of Crohn’s disease?
Terminal ileum, colon, ileum.
Describe lesions of Crohn’s disease.
They’re full-thickness lesions; inflammation involves the entire thickness of the colon.
What are some complications of Crohn’s disease?
Strictures, abscesses, fistulas.
What are skip lesions?
Discontinuous pattern of areas with lesions and normal areas. This is seen in Crohn’s disease.
What is the acute presentation of Crohn’s disease?
Full-thickness inflammation.
What is a hallmark of Crohn’s disease?
Noncaseating granulomatous inflammation.
What is the pathogenesis of Crohn’s disease?
- Causative agent enters the system 2. Dysfunction in innate immunity causes overactivation of T cells 3. Inflammatory cytokines get released 4. Destruction of intestinal mucosa.
What markers are associated with Crohn’s disease?
Various IgA/IgG markers.
What endoscopic findings are associated with Crohn’s?
Ulcers, swollen mucosa, pseudo polyps, cobblestone appearance.
What are buzz words for Crohn’s?
Skip lesions, creeping fat, transmural, granulomas, aphthous ulcers.
Erythema nodosum and pyoderma gangrenosum are likely to be associated with…
Crohn’s disease.
What are the major sites of ulcerative colitis?
Starts at the rectum and proceeds continuously up through the colon; only present in the colon.
Describe lesions of ulcerative colitis.
They involve the superficial mucosa only.
What markers are associated with ulcerative colitis?
pANCA and DNase-sensitive pANCA.
What are endoscopic findings of ulcerative colitis?
Diffuse mucosal disease and pseudo polyps.
What are buzz words for ulcerative colitis?
Pancolitis, retrograde, pseudopolyps, crypt abscess.
