Seziure Disorders Flashcards
What is a seizure ?
Sudden abnormal, excessive, electrical discharge of neurons in the brain
What is going on in the brain when a seizure is happening?
Paroxysmal; uncontrolled electrical discharge of neurons in brain that interrupts normal function
Seizure may accompany other discords or occur ___ without apparent cause
Spontaneously
Are seizures resulting from metabolic disturbances, like
Acidosis
Electrolyte imblanese
Hypoglycemia
Hypoxemia
Alcohol
Dehydration
Water intoxication
Considered epilepsy/seizures ?
And why?
No
Because it’s a underlying condition
And usually can be treated when underlying condition is fixed
What are the 4 extracranial diseases associated with seizures?
Heart ->
Lung ->
Liver ->
Kidneys ->
Hypertension
Systemic lupus erythematosus
Diabetes mellitus
Septicemia
What does epilepsy mean?
A seizure disorder
Since epilepsy is a seizure disorder, what else does that tell us? Define it
Usually caused by?
Condition in which a person has a spontaneously recurring seizures
And underlying chronic condition
In the United States, about ___ million people have epilepsy
And incidence increased in ___
3 million
Older adults
Etiology and pathophysiology
Many possible causes vary by ___
Mainly found in which race ?
Which type of people ?
Male or female?
High risk of epilepsy are in which disease?
Age
African American
Socially disadvantage
Makes
Alzheimer’s & stroke
For patients who don’t know the seizure disorder, it’s known to be called as?
Idiopathic generalized epilepsy (IGE)
Common causes during the first 6 months of life are ? (4) for seizures
Severe birth injury
Congenial birth deficits (CNS)
Infections
Inborn errors of metabolism
Common causes from ages 2-20
(4)
Birth injury
Infection
Trauma
Genetic factors
Common causes between 20-30
(3)
Structural lesions
- trauma
- brain tumor
- vascular disease
Common causes after 50?
(2)
Stroke
Metastatic brain tumors
In epilepsy, Abnormal neurons undergo spontaneous firing.
Where does firing of these neurons go to? (2)
( if activity involves whole brain, generalized seizure occurs )
What is the cause of this abnormal firing?
Adjacent or distant areas of the brain
Unknown
What is normally found in area of brain from which eplieptic activity arises?
Gliosis ( scar tissue )
Gliosis (scar tissue) is thought to interfere with normal what?
And this makes it more likely to ?
Chemical and structural environment of neurons
Fire abnormal neurons ( or have another seizure )
Notes
Genetic link
Genetic abnormalities may be the most important factor contributing to IGE, but difficult to separate from environmental or acquired influences
Some types of epilepsy run in families
Others type of IGE are related to specific genes
More than 500 genes play a role
What are the 3 classification of a seizure?
Determined by site of electrical disturbances
Divided into 2 major classes
Generalized and focal
Treatment is driven by type of seizure
Clinical manifestations of seizures may progress through several phases
Which are 4 of them ( name and define )
Notes
- not all patients have every phase
Prodromal - signs that precede seizures
Aural - sensory warning
Ictal phase - seizure
Postictal- rest and recovery
What are the 7 generalized onset seizure?
Tonic-clonic
Typical absence ( petit-mal )
Atypical absence
Myoclonic
Atonic
Tonic
Clonic
What is the most common seizure?
Tonic clonic
Tonic clonic ( also named as grand mal )
Is characterized by?
What is the tonic phase and time?
What is the clonic phase and time?
What are the 3 symptoms that occur?
Loss of consciousness and falling
Body stiffens ( 20secs )
Subsequent jerking of extremities
(30-40secs)
Cyanosis
Excessive salivation
Tongue/cheek biting
In the postictal phase ( after seizure, recovery and rest )
Patients are characterized by? (2)
Patient may sleep for ___
May not feel ___ for hours to days
They will no ___ of seizures
Muscle soreness and fatigue
Hours
Normal
Memory
What is a typical absence seizure ?
Usually happens only in?
May ceases as the child ?
Can be precipated by ? (2)
Usually occurs only in childern and rarely beyond adolescence
May cease as the child matures or develop into another type
Can be precipitated by flashing lights & hyperventilation
What is the typical symptoms of petit mal?
How does it last?
Often goes?
May occur up to how many times a day ?
What machine demonstrated pattern unique to this type of seizure?
Staring spell “daydreaming”
Few seconds
Unnoticed
100times
EEG
What is atypical absence seizure characterized by?
They usually have a what?
What type of behavior during seizure?
What behavior after ?
Staring spell with other manifestations that last longer than typical absence seizures
Brief warnings
Peculiar
Confusion
What is a myoclonic seizure?
This can be forceful enough that patients will end up ?
It can be brief seizure but also can occur in?
Charactered by sudden; excessive jerk of the body and extremities
Falling
Clusters
What’s atonic seizure?
This begins ___ and person falls
When does consciousness usually return?
( patients can resume normal activity immediately )
This has the greatest risk for ?
Involved tonic episode or paroxysmal loss of muscle tone
Suddenly
By the time the person hits the ground
Head injury
Tonic seizures are?
Patients often fall!!
Sudden onset of maintained increased tone in the extensor muscles
What is clonic seizures?
Followed by?
Begin with loss of consciousness and suddenly loss of muscle time
Limb jerking
What is a focal seizure caused by?
Where does it begin?
What does it produce?
Focal irritations
Specific region of cortex of brain
Signs and symptoms related to the function of the area if the brain involved
Focal seizures are also called?
Partial or partial focal seizures
Focal seizures are divided into 2
Simple and complex
Describe each forms of LOC
(1)(2)
Person remained conscious
Person has loss or change of LOC
Produce a dreamlike experience