sexual differentiation Flashcards
development of gonads from
intermediate mesoderm
when do male/female characteristics appear
wk6/7
where to primordial germ cells migrate to
genital ridges
vas deferens, epidydimus, seminal vesicles comes from
Wolffian duct
fallopian tubes and uterus. cervix, upper 1/3 vagina come from
mullerian duct (motheran duct)
primordial germ cells become
gametes
what sort of cells are semineferous tubules and ovarian follicles
mesothelial (leydig, sertoli, thecal, granulosa)
which gene determines maleness
SRY
what does sry protein bind with
sterogenic factor 1
what do sertoli cells produce
Mulleran inhibiting factor/anti-mulleran hormone
what does MIF do
degenerate uterus etc
46 XY DSD is caused by
mutation in SRY gene
what happens in in 46 XY DSD
no puberty primary amenorrhoea
present as female
infertility
no MIF
no testosterone
DHT forms
penis, prostate, scrotum
what is the thing which lowers the gonads
gubernaculum
what does gubernaculum become in women
round ligament
who has tunica vaginalis
boys
what does tunica vaginalis have in it
serous fluid to protect testes anteriorly
which muscles come down with the testes
internal and external oblique
what is internal oblique called inside the scrotum
cremaster
blood supply to ovary
anastamosis of uterine and ovarian arteries
lpelvic floor muscles
levator ani and perineal body
