Sex Detemination Etc Flashcards

1
Q

What is a sexual founder

A

The progeny is made up of half and half of the parents

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2
Q

What are the immediate benefits of sex

A

Increase in fitness
AIDS repair of deleterious mutations
Bi parental care

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3
Q

What are the long term benefits of sex

A

Beneficial combinations of alleles
Breaks up deleterious ones
Reduces sibling competition
Produces homo and hetro buffers

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4
Q

How many autosomal chromosome pairs do drosophila have

A

3

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5
Q

Which gene is turned off to produce males in drosophila

A

X:A = 0.5. Turns off sex-lethal

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6
Q

How is sex-lethal turned off in males

A

It’s spliced out

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7
Q

What sex can nematode worms C.elegans be?

A

Males or homafrodites

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8
Q

What initiates maleness in human?

A

The SRY gene on the Y chromosome

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9
Q

What does the SRY gene do?

A

Triggers the development of testies

Encodes protein with DNA binding domain

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10
Q

What animals sex is determined on the environment?

A

Lizards, reptiles, fish and worms

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11
Q

Why do females have to compensate for dosage of the X chromosome?

A

Because otherwise they would behave too many genes

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12
Q

What conditions can be produced when gene dosage goes wrong?

A

Trisomy 21 (Down syndrome) trisomy 18 and 13 which can cause spontaneous abortion and miscarriage

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13
Q

What is haploinsufficency?

A

Single gene mutations there isn’t enough gene dose (one allele isn’t enough single dosage)

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14
Q

How is the X chromosome shut down in humans

A

The Barr body shuts down the X chromosome can shut down multiple if an individual has multiple X chromosomes

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15
Q

What is Ohno’s law?

A

Extremely high conservation of genes on X chromosomes of therian mammals- synteny

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16
Q

What is turners syndrome?

A

1/5000 female live births
Most commonly associated with 45X karyotypes
1-2% all conceptions produces this child
99%. Don’t make it to term

17
Q

What are the complications with multiple X chromosomes

A

IQ reduction and 25% are infertile

Problems arise with having excess active genes

18
Q

What do you get from your mother but not your father?

A

Mitochondria

19
Q

How many mitochondria are there per cell?

A

100-1000s

20
Q

What did mitochondria originate as ?

A

Endosymbiotic bacteria capable of oxidative phosphorylation

21
Q

What are Y chromosome traits?

A

Stature, hypertension, coronas artery disease, tooth size, testicular/prostate cancer, aggression, non-syndromic deafness, HIV/AIDS progression

22
Q

Roughly how many genes has the Y chromosome lost?

A

900

23
Q

What is an asexual founder

A

Passes on all their genes to their progeny