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Phys Flashcards

1
Q

Name 5 recreational/abuse drugs

A 
Morphine
Benzodiazepines 
Nicotine
Cocaine
Alcohol
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2
Q

What do psychomotor stimulants do?

A

Cause wakefulness and euphoria

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3
Q

What do psychomimetrics do and an example

A

LSD

Cause disterbance of perception and behaviour

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4
Q

Drug targets in the CNS

A

Enzymes
Transport proteins
Ion channels
Receptors

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5
Q

Name 5 receptors

A 
Ionotropic receptors
G-protein coupled receptors
Kinase-linked receptors
Intracellular receptors
Tyrosine kinase receptors
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6
Q

What do benzodiazepines effect?

A

The GABAa ionotrophic receptor

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7
Q

Name 4 sustained action agonist (inhibitory) on the GABAa receptor

A

Diazepam
Alprazlam (Xanax)
Chlordiazepoxide
Clobazam

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8
Q

Name 2 short action drugs which are agonists to the GABAa receptor

A

Lorazepam

Oxazepam

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9
Q

What neurotransmitters are associated with depression?

A

Nor adrenaline (NA)
Serotonin (5-HT)
Dopamine (DA)

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10
Q

Name 5 tricyclic antidepressants with sedative properties

A 
Clompramine (anafranil) 
Doxepin (Sineprin)
Trimipramine (Surmontil)
Amitriptyline (triptafen, triptafen-M)
Dosulepin (dothiepin, prothiaden)
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11
Q

Name 3 tricyclic antidepressants with less sedative properties

A

Imipramine
Lofepramine
Nortriptyline (allegron)

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12
Q

Name 6 selective serotonin re-uptake inhibitors

A 
Citapram (Cipramil)
Fluoxetine (Prozac)
Paroxetine (seroxat)
Escitalopram (cipralex) 
Fluvoxamine (Faverin)
Sertraline (lustral)
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13
Q

Name 3 monoamine-oxidase inhibitors

A

Phenelzine (Nardil)
Isocarboxazid
Tranylcypromine

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14
Q

Name 1 reversible monoamine-oxidase inhibitor

A

Moclobemide (Manerix)

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15
Q

Name 3 drugs which can be used to treat manic epidodes/bipolar disorder (there are others but only need to know a few)

A 
Lithium/lithium carbonate
Benzodiazepines 
Camcolit
Others
Carbamazepine 
Priadel
Valproic acid
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16
Q

Name 3 types of benzodiazepines used in hypnotics

A 
Nitrazepam
Flurazepan
Loprazolam
Lormetazepam
Temazepam
17
Q

Name 3 non-BZD hypnotics

A

Zalepon
Zolpidem tartrate
Zopiclone

18
Q

Name 3 antiepileptics

A

Phenytoin
Carbamazepine
Lamotrigine

19
Q

How does heterosynaptic facilitation work?

A
  1. 5-HT activates metabotrophic 5-HT receptor
  2. 5-HT receptor activates adenylate Cyclase
  3. Increase in intracellular cAMP concentration
  4. cAMP activates protein kinase A
  5. PKA phosphorylase so voltage-gated K+ channel reduction in K+ current during ap broadening the ap
  6. Voltage-gated Ca++ channels open longer more influx
  7. Higher Ca++ concentration more transmitter release
20
Q

Just 4 therapeutic drugs

A

Morphine
Benzodiazepines
Antidepressants
Antipsychotics

Genomes (8 decks)

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