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ANPH 500 - Pharmacology - McCarver > Sevoflurane > Flashcards

Sevoflurane Flashcards

0
Q

No more than __ carbon atoms, non flammable, and stable to soda lime

A

Four

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1
Q

Is sevo a methyl isopropyl ether or a methyl ethyl ether?

A

Methyl isopropyl ether

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2
Q

Fully halogenated compounds are usually __ anesthetics and convulsants

A

Poor

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3
Q

Metabolism rate of sevo

A

3-5%

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4
Q

Blood gas partition coefficient of sevo

A

0.69

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5
Q

Sevo is __ an airway irritant

A

Not really

Can do a one breath sevo induction

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6
Q

How many fluorine atoms on sevo?

A

Seven

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7
Q

Des is synthesized from __

A

ISO

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8
Q

Mac of sevo

A

2.1%

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9
Q

Addition of nitrous __ mac of sevo

A

Decreases

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10
Q

Mac awake __

A

0.3 x mac (2.1)

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11
Q

Mac BAR

A

1.5x mac

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12
Q

Mac intubation

A

2x mac

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13
Q

Hypothermia, increased age, benzo, opiates, alpha2 agonists, nitrous, pregnancy, acute ethanol, sick, hypoNA, hyperMag
All __ mac

A

Decrease

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14
Q

CNS catecholamine stim, chronic ethanol, hyperNa

All __ mac

A

Increase

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15
Q

The lower the BGPC, the __ alveolar conc equilibrates to arterial conc

A

Quicker

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16
Q

Low solubility of sevo facilitates __ lung elimination

A

Rapid

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17
Q

Sevo vapor pressure

A

160 mmHg

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18
Q

Increased ventilation = __ equilibration

A

Quicker

19
Q

Increased cardiac output = __ equilibration

A

Slower

20
Q

Sevo could equilibrate in __ minutes in the vessel rich group

A

4-8

21
Q

Can sevo provide retrograde amnesia or long term impairment of intellectual function?

A

NO

22
Q

Sevo __ reduce cerebral metabolic oxygen requirements

A

Will

23
Q

Sevo has the potential to increase ICP in patients with space occupying lesions not receiving hyperventilation.

A

Slide 37
It is a cerebral blood vessel dilator
Treat by hyperventilate to end tidal CO2 around 30

24
Q

Around 2 mac you may have an __ EEG

A

Isoelectric

25
Q

Sevo does not produce seizures and can actually __ seizure activity

A

Suppress

26
Q

Sevo increases cerebral blood flow for up to __ hours

A

Four

27
Q

Hyperventilate to an end tidal CO2 of __ to counteract increased cerebral blow flow

A

30

28
Q

Sevo iso des ALL lower BP by decreasing __

A

SVR

29
Q

Sevo __ delivery of NMB

A

Enhances

30
Q

Sevo and right to left shunt?

A

Yes

31
Q

Sevo has __ effect on PVR

A

No

32
Q

Spontaneous ventilation causes CO, SBP, and SVR to __ more, but HR will increase more

A

Decrease

33
Q

Can you abruptly change concentrations in sevo?

A

Yes, unlike iso and des

34
Q

Inhalation induction with a sick heart?

A

NO

35
Q

Sevo causes apnea around

A

1.5-2 mac

36
Q

Sevo breathing is like a lizard on a hot rock

A

Small tidal, fast rate, decreased minute ventilation, increased CO2

37
Q

The ventilatory effects __ over time

A

Decrease

38
Q

Does sevo have muscle relaxant properties?

A

Yes, weak

39
Q

__ is the best way to counteract the ventilatory effects of sevo

A

Put a garden hose down their gullet

40
Q

Sevo is a __ bronchodilator and can break an attack of status asthmaticus

A

Potent

41
Q

Where is sevo metabolized?

A

Liver by cytochrome p450

42
Q

If your patient has a hx of post anesthesia hepatitis, that cannot occur with use of __
ONLY SEVO cannot be implicated in post-anesthetic hepatotoxicity.

A

Sevo

43
Q

What is a byproduct of sevo metabolism that is nephrotoxic?

A

Free fluoride

44
Q

Two bad compounds that sevo can metabolized into?

A

Compound A

HFIP

45
Q

Amsorb produces the lowest concentration of compound _

A

A

Test question

46
Q

Keep sevo __ during obstetrics due to uterine atony and possible hemorrhage

A

Minimal

ANPH 500 - Pharmacology - McCarver (11 decks)

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