benzo Flashcards
what are the five principle effects of benzos
sedation anxiolysis anticonvulsant skeletal muscle relaxation anterograde amnesia
benzos work on __ receptor
GABA A , chloride , hyperpolarization , inhibitory
__ reverses benzos
flumazenil
do benzos induce microsomal enzymes?
no
benzos vs. barbs
less tolerance less abuse potential greater margin of safety fewer drug reactions less addiction potential
benzos give you retrograde or anterograde amnesia?
anterograde (new information)
NOT retrograde (stored information)
should you change your NMB dose due to benzos?
no, muscle relaxation due to central origin, NOT at neuromuscular junction
benzos are drugs with a __ ring fused to a __ ring
benzene ring
diazepine ring
5-aryl substituent and 1,4 diazepine ring
what is the principle INHIBITORY neurotransmitter in the CNS?
GABA
benzos enhance opening of __ gated channels resulting in __polarization and rendering them resistant to excitation
chloride gated
hyperpolarization
do benzos, barbs, and alcohol work on the same physical receptor site?
no, different sites and mechanisms, but cross tolerance possible
most common side effects of benzos?
fatigue and drowsiness
sedation usually disappears in 2 weeks
benzos have no significant BP or HR effects, but __ ventilation effects
minimal
do benzos suppress adrenal cortisol levels?
yes
two pathways for metabolism of benzos
- glucuronidation
- hepatic microsomal enzyme metabolism
