Set 3

Question 1

intracellular recepetors

Answer 1

lipid-soluble ligand that crosses the membrane

Question 2

intracellular receptor examples

Answer 2

corticosteroids, mineral corticoids, sex steroids, vitamin D and thyroid hormone

Question 3

intercellular rec stimulate the transcription of genes in the nucleus by binding where

Answer 3

to specific DNA sequences near the gene whose expression is to be regulated

Question 4

target genes regulated =

Answer 4

response

Question 5

steroid makes way through membrane then binds to

Answer 5

ligand binding domain

Question 6

T/F drugs produce their effects after a characteristic lag period

Answer 6

True

Question 7

how long to alter pathologic state

Answer 7

hours/days

Question 8

T/F the effects of these agents can persist after the agonist con has been reduced to zero

Answer 8

True the drug is gone but the change is still there

Question 9

the persistence may be due to the ___ affinity of receptors for the hormone

Answer 9

high

Question 10

“non”receptor receptors are

Answer 10

effector enzymes that regulate cellular function including membrane potential, protein, translation

Question 11

non-receptor examples include

Answer 11

adenylyl cyclase, phospholipase, kinase, phosphates, and ubquitinases

Question 12

cytokine receptors

Answer 12

cytokine binds-conformational change-janus kinase binds- socs phosphorylates-binds to stat-dimerizes-gene regulation

Question 13

cytokine receptor examples

Answer 13

growth hormone, erythropoietin and interferons

Question 14

protein tyrosine kinases is also refered to as

Answer 14

ligand-regulated transmembrane enzymes

Question 15

protein tyrosine kinases add

Answer 15

phosphate group to a substrate

Question 16

protein tyrosine kinase examples are

Answer 16

insulin, epidermal growth factors, platelet derived growth factor

Question 17

protein tyrosine kinase consist of what 2 domains

Answer 17

extracellular hormone-binding domain and a cytoplasmic enzyme domain

Question 18

protein tyrosine kinase does what

Answer 18

puts phosphate on a tyrosine

Question 19

T/F protein tyrosine kinase span the lipid bilayer one time

Answer 19

True

Question 20

T/F protein tyrosine kinase act as dimers

Answer 20

True

Question 21

protein tyrosine kinase bind to the ___ domain and induces a conformational change

Answer 21

extracellular

Question 22

T/F tyrosine phosphorylation stops receptors from recruiting proteins

Answer 22

False, they allow receptors to recruit proteins

Question 23

the duration and intensity of the action is limited by

Answer 23

receptor down regulation

Question 24

upon ligand binding, endocytosis of the receptor is

Answer 24

stimulated

Question 25

T/F protein tyrosine kinase hard to inactivate and to stop to usually block the binding

Answer 25

True

Question 26

ion channels include what 2 types

Answer 26

voltage activated Na channel and ligand gated Na channel

Question 27

voltage channels are open by what

Answer 27

voltage or positive ions

Question 28

Example of voltage channels

Answer 28

Na, Ca2, K

Question 29

how can voltage channels be regulated

Answer 29

phosphorylation and Gproteins

Question 30

ligand gated channels examples

Answer 30

acetylcholine, gamma-aminobutryic acid, excitatory amino acid (glycine, aspartate, glutamate)

Question 31

how fast do is the response between binding of the agonist to the ligan gated channel

Answer 31

miliseconds

Question 32

GABA A recepters

Answer 32

protein with 5 subunits, 4 transmembrane each, losts of allosteric sites

Question 33

NMDA receptors

Answer 33

conduct sodium and calcium becomes depolarized more pos

Question 34

G-protein coupled receptors

Answer 34

7 transmembrane domain receptors coupled to Gproteins, alpha subunits

Question 35

EARL SUTHERLAND FOUND WHAT

Answer 35

cyclic AMP, camp

Question 36

how many GPCRs in the human genome

Answer 36

800

Question 37

T/F GPCRs are very popular drug target

Answer 37

True