Exam 3 intro ADME Flashcards
what does ADME mean
absorption, distribution, metabolism, excretion
JB cannot fall asleep but once asleep stays asleep, TB can fall asleep fast but wakes up every 2 h, what sedative differs
JB needs fast acting, TB needs long acting
what quantifies drug effect
onset, duration, intensity
what determines the drug effects
the concentration versus time profile after drug administration
on a graph what relates to the onset, duration, and intensity
onset-when the drug starts taking effect
duration- from onset to MEC
intensity- highest number
study slide 8
pharmacokinetics
the study of the absorption, distribution, biotransformation, and elimination if xenobiotics
pharmacodynamics
the study of the molecular, biochemical, and physiological effects of xenobiotics and their mechanisms of action
drug disposition is
the fate of a drug after it has entered the systemic circulation
T/F absorption to distribution, distribution to excretion, and metabolism forwards and back to distribution
true
pharmacotherapeutics
the rational use of drug necessitates an understanding of the ADME properties of drugs
T/F development of improved preclinical ADME has greatly reduced drug attrition due to poor PK/bioavailability
TRUE
rank the routes of administration of a con vs time graph
intravenously, intranasal, oral, smokes
T/F barriers to absorption can reduce the speed and/or extent by which drug enters the systemic curcutlation
True
a reduction in the extent of absorption will impact which of the three measures of pharmacologic effect
intensity
